tert-Butyl octahydropyrrolo[3,4-d]azepine-2(1H)-carboxylate hydrochloride | 1841081-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: tert-Butyl octahydropyrrolo[3,4-d]azepine-2(1H)-carboxylate hydrochloride
• 英文别名: tert-butyl 3,3a,4,5,6,7,8,8a-octahydro-1H-pyrrolo[3,4-d]azepine-2-carboxylate;hydrochloride
• CAS: 1841081-39-7
• 化学式: C13H25ClN2O2
• 分子量: 276.8
• InChiKey: MECGCBQVVDFPSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  41.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS<br/>[FR] COMPOSÉS BICYCLIQUES EN TANT QU'INHIBITEURS DE PRODUCTION D'AUTOTAXINE (ATX) ET D'ACIDE LYSOPHOSPHATIDIQUE (LPA)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015144605A1

  公开（公告）日：2015-10-01

  The invention provides novel compounds having the general formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds. The compounds of formula (I) are useful as autotaxin (ATX) inhibitors which are inhibitors of lysophosphatidic acid (LPA) production and thus modulators of LPA levels and associated signaling; in particular they are useful for the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.

  该发明提供了具有通式（I）的新化合物，其中R1、R2、A、W、m、n、p和q如本文所述，包括这些化合物的组合物。通式（I）的化合物可用作自体税肽酶（ATX）抑制剂，这些抑制剂是溶磷脂酸（LPA）产生的抑制剂，从而调节LPA水平和相关信号传导；特别是它们可用于治疗或预防肾脏疾病、肝脏疾病、炎症性疾病、神经系统疾病、呼吸系统疾病、血管和心血管疾病、纤维化疾病、癌症、眼部疾病、代谢性疾病、胆汁淤积和其他形式的慢性瘙痒以及急性和慢性器官移植排斥反应的治疗。
• [EN] NEW OCTAHYDRO-PYRROLO[3,4-C]-PYRROLE DERIVATIVES AND ANALOGS THEREOF AS AUTOTAXIN INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS D'OCTAHYDRO-PYRROLO [3,4-C]-PYRROLE ET ANALOGUES DE CEUX-CI SERVANT D'INHIBITEURS D'AUTOTAXINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014139978A1

  公开（公告）日：2014-09-18

  The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

  该发明提供了具有一般公式(I)的新化合物，其中R1、Y、A、W、R2、m、n、p和q如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• NEW BICYCLIC DERIVATIVES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150353559A1

  公开（公告）日：2015-12-10

  The invention provides novel compounds having the general formula (I) wherein R 1 , Y, A, W, R 2 , m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有一般式(I)的新化合物，其中R1、Y、A、W、R2、m、n、p和q如此处所述，包括该化合物的组合物以及使用该化合物的方法。
• NEW OCTAHYDRO-PYRROLO[3,4-c]-PYRROLE DERIVATIVES AND ANALOGS THEREOF AS AUTOTAXIN INHIBITORS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150376194A1

  公开（公告）日：2015-12-31

  The invention provides novel compounds having the general formula (I) wherein R 1 , Y, A, W, R 2 , m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有一般式(I)的新化合物，其中R1、Y、A、W、R2、m、n、p和q如本文所述，以及包括该化合物的组合物和使用该化合物的方法。
• Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
  申请人：Hoffmann-La Roche Inc.

  公开号：US10654857B2

  公开（公告）日：2020-05-19

  Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.

  式(I)化合物 其中 R1、R2、A、W、m、n、p 和 q 如本文所述。