3,6,9,12-tetrakis(diethoxyphosphoryl)-3,6,9,12-tetraazabicyclo[12.3.1]octadeca-1(18),14,16-triene | 281193-17-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 3,6,9,12-tetrakis(diethoxyphosphoryl)-3,6,9,12-tetraazabicyclo[12.3.1]octadeca-1(18),14,16-triene
• 英文别名: 3,6,9,12-Tetrakis(diethoxyphosphoryl)-3,6,9,12-tetrazabicyclo[12.3.1]octadeca-1(18),14,16-triene
• CAS: 281193-17-7
• 化学式: C₃₀H₆₀N₄O₁₂P₄
• 分子量: 792.721
• InChiKey: FZFKTVWEATZAOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  50
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  155
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  3,6,9,12-tetrakis(diethoxyphosphoryl)-3,6,9,12-tetraazabicyclo[12.3.1]octadeca-1(18),14,16-triene 在 盐酸 、 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 以90%的产率得到3,6,9,12-tetraazabicyclo[12.3.1]octadeca-1(18),14,16-triene
  参考文献：
  名称：

  Diethoxyphosphoryl as a Protecting-Activating Group in the Synthesis of Polyazacyclophanes

  摘要：

  The fully diethoxyphosphoryl(Dep)-protected polyamines 1b-3b were prepared from the corresponding polyamines with 'diethyl phosphite' (= diethyl phosphonate) and CCl4 in a solid base/organic liquid two-phase system in the presence of Bu4NBr as phase-transfer catalyst. Subsequent phase-transfer-catalyzed alkylation of phosphoramidates 1b-3b with bis(chloromethyl)arenes 5-8 in the presence of Bu4N(HSO4) followed by deprotection gave good yields of polyazacyclophanes 9a-16a.

  DOI：

  10.1002/(sici)1522-2675(20000412)83:4<793::aid-hlca793>3.0.co;2-3
• 作为产物：
  描述：

  间二氯苄 、 N,N'-1,2-乙烷二基二[N-[2-[(二乙氧基亚膦酰)氨基]乙基]-氨基磷酸 P,P,P',P'-四乙基酯 在 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 甲苯 为溶剂， 以73%的产率得到3,6,9,12-tetrakis(diethoxyphosphoryl)-3,6,9,12-tetraazabicyclo[12.3.1]octadeca-1(18),14,16-triene
  参考文献：
  名称：

  Diethoxyphosphoryl as a Protecting-Activating Group in the Synthesis of Polyazacyclophanes

  摘要：

  The fully diethoxyphosphoryl(Dep)-protected polyamines 1b-3b were prepared from the corresponding polyamines with 'diethyl phosphite' (= diethyl phosphonate) and CCl4 in a solid base/organic liquid two-phase system in the presence of Bu4NBr as phase-transfer catalyst. Subsequent phase-transfer-catalyzed alkylation of phosphoramidates 1b-3b with bis(chloromethyl)arenes 5-8 in the presence of Bu4N(HSO4) followed by deprotection gave good yields of polyazacyclophanes 9a-16a.

  DOI：

  10.1002/(sici)1522-2675(20000412)83:4<793::aid-hlca793>3.0.co;2-3

文献信息

• Synthesis of an azacrown template for phosphatidylinositol-4,5-bis(phosphate) recognition
  作者：Charles W. Gray、Kathleen Barry、Eric J. Lindberg、Todd A. Houston

  DOI：10.1016/j.tetlet.2007.02.073

  日期：2007.4

  An azacrown system has been developed for selective membrane binding of phosphatidylinositol-4,5-bis(phosphate) recognition. Neutral and cationic forms of the metacyclophane macrocycles have been synthesized by divergent routes in acceptable yields. Such diversity will be useful in identifying anion receptors that operate best at membrane interfaces. (c) 2007 Elsevier Ltd. All rights reserved.
• Diethoxyphosphoryl as a Protecting-Activating Group in the Synthesis of Polyazacyclophanes
  作者：Andrea Chellini、Roberto Pagliarin、Giovanni B. Giovenzana、Giovanni Palmisano、Massimo Sisti

  DOI：10.1002/(sici)1522-2675(20000412)83:4<793::aid-hlca793>3.0.co;2-3

  日期：2000.4.12

  The fully diethoxyphosphoryl(Dep)-protected polyamines 1b-3b were prepared from the corresponding polyamines with 'diethyl phosphite' (= diethyl phosphonate) and CCl4 in a solid base/organic liquid two-phase system in the presence of Bu4NBr as phase-transfer catalyst. Subsequent phase-transfer-catalyzed alkylation of phosphoramidates 1b-3b with bis(chloromethyl)arenes 5-8 in the presence of Bu4N(HSO4) followed by deprotection gave good yields of polyazacyclophanes 9a-16a.