(3R)-3-methyl-8-azaspiro[4.5]decane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: (3R)-3-methyl-8-azaspiro[4.5]decane
• 化学式: C₁₀H₁₉N
• 分子量: 153.26
• InChiKey: JTTHNODDZCODAT-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] MACROCYCLIC 2-AMINO-3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1<br/>[FR] 2-AMINO-3-FLUORO-BUT-3-ÉNAMIDES MACROCYCLIQUES UTILISÉS COMME INHIBITEURS DE MCL-1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2021250102A1

  公开（公告）日：2021-12-16

  The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds (formula (I)), and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.

  本发明涉及用于治疗和/或预防受试者的药物剂，包括这些化合物（式（I）），以及它们作为MCL-1抑制剂的药物组合物，用于治疗癌症等疾病。
• [EN] SUBSTITUTED PHENYL-1H-PYRROLO [2, 3-c] PYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE PHÉNYL-1H-PYRROLO [2, 3-C] PYRIDINE SUBSTITUÉS
  申请人：[en]JANSSEN PHARMACEUTICA NV

  公开号：WO2022253167A1

  公开（公告）日：2022-12-08

  The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.