dodecyl 2-(methylamino)ethyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: dodecyl 2-(methylamino)ethyl hydrogen phosphate
• 化学式: C₁₅H₃₄NO₄P
• 分子量: 323.41
• InChiKey: DGEQENOSOTUARM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-Dodecyloxy-3-methyl-1,3,2-oxazaphosphacyclopentane 2-oxide 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 以58 %的产率得到dodecyl 2-(methylamino)ethyl hydrogen phosphate
  参考文献：
  名称：

  发现新型氧氮杂磷脂，用于快速、稳健地合成磷脂酰乙醇胺作为药物输送的优异载体

  摘要：

  通过应用新发现的氧杂磷啶，通过酯交换和水解，开发了一种快速、高效和稳健的磷脂酰乙醇胺合成方法。该方案反应条件温和、操作简单、纯化方便，为构建一类具有潜在价值的药物输送磷脂酰乙醇胺提供了一条高效、直接的途径。

  DOI：

  10.1016/j.tetlet.2023.154754

文献信息

• McGuigan, Christopher; Swords, Bernadette, Journal of the Chemical Society. Perkin transactions I, 1990, p. 783 - 787
  作者：McGuigan, Christopher、Swords, Bernadette

  DOI：——

  日期：——
• MCGUIGAN, CHRISTOPHER;SWORDS, BERNADETTE, J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 783-787
  作者：MCGUIGAN, CHRISTOPHER、SWORDS, BERNADETTE

  DOI：——

  日期：——
• Methods and kits for obtaining nucleic acid from biological samples
  申请人：Montesclaros Luz

  公开号：US20050009036A1

  公开（公告）日：2005-01-13

  Methods and kits for isolating nucleic acids from a sample, typically a biological sample are disclosed. In certain embodiments, the methods and kits of the invention comprise at least one protease and at least one solid phase. In certain embodiments, the methods and kits of the invention comprise at least one chaotrope and at least one solid phase. In certain embodiments, the inventive methods and kits further comprise at least one chaotrope, at least one zwitterionic compound, at least one cationic detergent, at least one non-ionic detergent, or combinations thereof.
• [EN] METHODS AND KITS FOR OBTAINING NUCLEIC ACID FROM BIOLOGICAL SAMPLES<br/>[FR] METHODES ET KITS PERMETTANT D'OBTENIR DES ACIDES NUCLEIQUES A PARTIR D'ECHANTILLONS BIOLOGIQUES
  申请人：APPLERA CORP

  公开号：WO2005007895A1

  公开（公告）日：2005-01-27

  Methods and kits for isolating nucleic acids from a sample, typically a biological sample are disclosed. In certain embodiments, the methods and kits of the invention comprise at least one protease and at least one solid phase. In certain embodiments, the methods and kits of the invention comprise at least one chaotrope and at least one solid phase. In certain embodiments, the inventive methods and kits further comprise at least one chaotrope, at least one zwitterionic compound, at least one cationic detergent, at least one non-ionic detergent, or combinations thereof.