5-chloro-2,3-dihydrobenzoxazole | 1361534-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑啉
• 英文名称: 5-chloro-2,3-dihydrobenzoxazole
• 英文别名: 5-Chloro-2,3-dihydro-1,3-benzoxazole
• CAS: 1361534-17-9
• 化学式: C₇H₆ClNO
• 分子量: 155.584
• InChiKey: PXMDCAGIWSJFLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二氯乙酰氯 、 5-chloro-2,3-dihydrobenzoxazole 以 N,N-二甲基乙酰胺 为溶剂， 反应 2.0h， 以82%的产率得到N-dichloroacetyl-5-chloro-2,3-dihydrobenzoxazole
  参考文献：
  名称：

  Synthesis and biological activity of some novel N-dichloroacetyl-2,3-dihydrobenzoxazole derivatives

  摘要：

  A facile synthetic route was developed to N-dichloroacetyl-2,3-dihydrobenzoxazole derivatives 3 by cycloaddition of 2-amino-phenol (1) with dichloromethane and acylation of the resultant intermediate 2,3-dihydrobenzoxazole 2 with dichloroacetyl chloride. The structures of the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectroscopy and elemental analysis. The preliminary biological tests showed that products 3 could protect maize against injury caused by acetochlor to some extent.

  DOI：

  10.1515/hc.2011.010
• 作为产物：
  描述：

  二氯甲烷 、 4-氯-2-氨基苯酚 在 sodium hydroxide 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 1.0h， 以73%的产率得到5-chloro-2,3-dihydrobenzoxazole
  参考文献：
  名称：

  Synthesis and biological activity of some novel N-dichloroacetyl-2,3-dihydrobenzoxazole derivatives

  摘要：

  A facile synthetic route was developed to N-dichloroacetyl-2,3-dihydrobenzoxazole derivatives 3 by cycloaddition of 2-amino-phenol (1) with dichloromethane and acylation of the resultant intermediate 2,3-dihydrobenzoxazole 2 with dichloroacetyl chloride. The structures of the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectroscopy and elemental analysis. The preliminary biological tests showed that products 3 could protect maize against injury caused by acetochlor to some extent.

  DOI：

  10.1515/hc.2011.010

文献信息

• Thermoplastic resin composition
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US10113049B2

  公开（公告）日：2018-10-30

  [Problem] Provided is a thermoplastic resin composition excellent in weather resistance. [Solution] A thermoplastic resin composition containing (a) a thermoplastic resin and (b) an ionically bonded salt represented by the following Chemical Formula (1) or (2): in the Chemical Formulae (1) and (2) above, R1 and R2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, a pyrrolinium ion, a piperidinium ion, a pyrazinium ion, a pyrimidinium ion, a triazolium ion, a triazinium ion, a quinolinium ion, an isoquinolinium ion, an indolinium ion, a quinoxalinium ion, a piperazinium ion, an oxazolinium ion, a thiazolinium ion, and a morpholinium ion.

  [问题]提供一种耐候性优异的热塑性树脂组合物。 [解决方案] 一种热塑性树脂组合物，含有 (a) 热塑性树脂和 (b) 由以下化学式（1）或（2）表示的离子键盐： 在上述化学式（1）和（2）中，R1 和 R2 各自独立地代表具有 1 至 30 个碳原子的取代或 未取代的直链、支链或环状烷基、具有 6 至 30 个碳原子的取代或未取代的芳基或具有 7 至 31 个碳原子的取代或未取代的芳烷基，A 是具有 2 至 4 个碳原子的直链或支链亚烷基，n 代表 0 至 50 的整数、Q1 和 Q2 各自独立地代表至少一种选自以下组成的组的物质：铵离子、咪唑鎓离子、吡啶鎓离子、吡咯烷鎓离子、吡咯烷鎓离子、哌啶鎓离子、吡嗪鎓离子嘧啶鎓离子、三唑鎓离子、三嗪鎓离子、喹啉鎓离子、异喹啉鎓离子、吲哚鎓离子、喹喔啉鎓离子、哌嗪鎓离子、噁唑啉鎓离子、噻唑啉鎓离子和吗啉鎓离子。
• QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS
  申请人：Southern Research Institute

  公开号：EP2744787B1

  公开（公告）日：2016-11-02
• Co-Administration of An Agent Linked to an Internalization Peptide With an Anti-Inflammatory
  申请人：Tymianksi Michael

  公开号：US20120252731A1

  公开（公告）日：2012-10-04

  The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
• CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY
  申请人：NoNO Inc.

  公开号：US20150126460A1

  公开（公告）日：2015-05-07

  The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
• THERMOPLASTIC RESIN COMPOSITION
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US20150329698A1

  公开（公告）日：2015-11-19

  [Problem] Provided is a thermoplastic resin composition excellent in weather resistance. [Solution] A thermoplastic resin composition containing (a) a thermoplastic resin and (b) an ionically bonded salt represented by the following Chemical Formula (1) or (2): in the Chemical Formulae (1) and (2) above, R 1 and R 2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, a pyrrolinium ion, a piperidinium ion, a pyrazinium ion, a pyrimidinium ion, a triazolium ion, a triazinium ion, a quinolinium ion, an isoquinolinium ion, an indolinium ion, a quinoxalinium ion, a piperazinium ion, an oxazolinium ion, a thiazolinium ion, and a morpholinium ion.