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    —— tert-butyl N-[(2S)-1-[[3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate —— C27H36FN7O3
    tert-butyl N-[(2S)-1-[[3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[2-[3-chloro-5-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]-2-oxoethyl]carbamate —— C28H35ClN8O4
    tert-butyl N-[2-[3-chloro-5-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]-2-oxoethyl]carbamate
    —— tert-butyl N-[3-[2-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]carbamate —— C25H30N6O2
    tert-butyl N-[3-[2-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]carbamate
    —— tert-butyl N-[(1S,3R)-3-[2-(3-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]cyclohexyl]carbamate —— C25H34N6O2
    tert-butyl N-[(1S,3R)-3-[2-(3-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]cyclohexyl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[4-[cyclopropyl(propyl)amino]-2-[(2-fluoropyridin-4-yl)amino]pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C29H40FN7O3
    tert-butyl N-[(2S)-1-[5-[4-[cyclopropyl(propyl)amino]-2-[(2-fluoropyridin-4-yl)amino]pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(5-fluoropyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C26H36FN7O3
    tert-butyl N-[(2S)-1-[5-[2-[(5-fluoropyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(1S,3R)-3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-morpholin-4-ylpyrimidin-5-yl]ethynyl]cyclohexyl]carbamate —— C26H33FN6O3
    tert-butyl N-[(1S,3R)-3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-morpholin-4-ylpyrimidin-5-yl]ethynyl]cyclohexyl]carbamate
    —— tert-butyl (E)-4-(3,5-dimethylpiperazin-1-yl)but-2-enoate —— C14H26N2O2
    tert-butyl (E)-4-(3,5-dimethylpiperazin-1-yl)but-2-enoate
    —— tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate —— C28H39N9O3
    tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate
    —— tert-butyl N-[(2R)-1-oxo-1-[3-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]propan-2-yl]carbamate —— C29H38N8O4
    tert-butyl N-[(2R)-1-oxo-1-[3-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]propan-2-yl]carbamate
    —— tert-butyl N-[2-[[4-[2-(4-carbamoylanilino)-4-(propylamino)pyrimidin-5-yl]phenyl]methylamino]-2-oxoethyl]carbamate —— C28H35N7O4
    tert-butyl N-[2-[[4-[2-(4-carbamoylanilino)-4-(propylamino)pyrimidin-5-yl]phenyl]methylamino]-2-oxoethyl]carbamate
    —— tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(2-methyl-1,3-benzothiazol-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate —— C29H39N7O3S
    tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(2-methyl-1,3-benzothiazol-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate
    —— tert-butyl (3-(3-aminophenyl)-2,2,3-trifluoropropyl)carbamate —— C14H19F3N2O2
    tert-butyl (3-(3-aminophenyl)-2,2,3-trifluoropropyl)carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(2-methoxyethylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C28H37N7O4
    tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(2-methoxyethylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-(cyclopropylamino)-4-[(6-methoxypyridin-3-yl)amino]pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C27H37N7O4
    tert-butyl N-[(2S)-1-[5-[2-(cyclopropylamino)-4-[(6-methoxypyridin-3-yl)amino]pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)-3-methylpyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C31H45N9O4
    tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)-3-methylpyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[[(1S,3R)-3-[2-[4-ethoxy-2-(3-fluoroanilino)pyrimidin-5-yl]ethynyl]cyclohexyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate —— C29H38FN5O4
    tert-butyl N-[(2S)-1-[[(1S,3R)-3-[2-[4-ethoxy-2-(3-fluoroanilino)pyrimidin-5-yl]ethynyl]cyclohexyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(1,3-dimethylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C29H41N9O3
    tert-butyl N-[(2S)-1-[5-[2-[(1,3-dimethylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-methyl-N-[(2S)-1-oxo-1-[5-[4-(propylamino)-2-(quinolin-3-ylamino)pyrimidin-5-yl]pent-4-ynylamino]propan-2-yl]carbamate —— C30H39N7O3
    tert-butyl N-methyl-N-[(2S)-1-oxo-1-[5-[4-(propylamino)-2-(quinolin-3-ylamino)pyrimidin-5-yl]pent-4-ynylamino]propan-2-yl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(3-methoxy-1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C29H41N9O4
    tert-butyl N-[(2S)-1-[5-[2-[(3-methoxy-1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)indazol-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C31H44N8O4
    tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)indazol-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[3-[[2-(4-carbamoylanilino)-4-(propylamino)-1,4-dihydropyrimidine-5-carbonyl]amino]propyl]carbamate —— C23H35N7O4
    tert-butyl N-[3-[[2-(4-carbamoylanilino)-4-(propylamino)-1,4-dihydropyrimidine-5-carbonyl]amino]propyl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(3-methoxypropylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C29H39N7O4
    tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(3-methoxypropylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl (2S)-2-[5-[2-[(3-methoxy-1-methylindazol-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C31H42N8O4
    tert-butyl (2S)-2-[5-[2-[(3-methoxy-1-methylindazol-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate
    —— tert-butyl (2S,4R)-2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]-4-hydroxy-2-methylpyrrolidine-1-carboxylate —— C30H39N7O4
    tert-butyl (2S,4R)-2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]-4-hydroxy-2-methylpyrrolidine-1-carboxylate
    —— tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(cyclopentylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C30H39N7O3
    tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(cyclopentylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(2-methylquinolin-6-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate —— C31H41N7O3
    tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(2-methylquinolin-6-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(3-methoxy-1-methylindazol-6-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C30H42N8O4
    tert-butyl N-[(2S)-1-[5-[2-[(3-methoxy-1-methylindazol-6-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]carbamate —— C23H29FN6O2
    tert-butyl N-[3-[2-[2-[(2-fluoropyridin-4-yl)amino]-4-(propylamino)pyrimidin-5-yl]ethynyl]cyclobutyl]carbamate
    —— tert-butyl (2S,4R)-4-methyl-2-[5-[4-[11-methyl-6-[2-[(2S,4R)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-11-azatricyclo[6.2.1.02,7]undeca-2,4,6-trien-3-yl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate —— C43H55N7O4
    tert-butyl (2S,4R)-4-methyl-2-[5-[4-[11-methyl-6-[2-[(2S,4R)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-11-azatricyclo[6.2.1.02,7]undeca-2,4,6-trien-3-yl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate
    —— tert-butyl (3-(4-(propylamino)-2-(3-(pyridin-4-yl)ureido)pyrimidine-5-carboxamido)propyl)carbamate —— C22H32N8O4
    tert-butyl (3-(4-(propylamino)-2-(3-(pyridin-4-yl)ureido)pyrimidine-5-carboxamido)propyl)carbamate
    —— tert-butyl (2S)-2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C29H37N7O3
    tert-butyl (2S)-2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate
    —— tert-butyl (2S)-2-[5-[2-[(1,3-dimethylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C30H41N9O3
    tert-butyl (2S)-2-[5-[2-[(1,3-dimethylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate
    —— tert-butyl N-[2-methyl-1-oxo-1-[3-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]propan-2-yl]carbamate —— C30H40N8O4
    tert-butyl N-[2-methyl-1-oxo-1-[3-[[4-(propylamino)-2-(2-pyridin-4-ylethylamino)pyrimidine-5-carbonyl]amino]anilino]propan-2-yl]carbamate
    —— tert-butyl N-methyl-N-[(2S)-1-oxo-1-[5-[4-(propylamino)-2-(quinolin-6-ylamino)pyrimidin-5-yl]pent-4-ynylamino]propan-2-yl]carbamate —— C30H39N7O3
    tert-butyl N-methyl-N-[(2S)-1-oxo-1-[5-[4-(propylamino)-2-(quinolin-6-ylamino)pyrimidin-5-yl]pent-4-ynylamino]propan-2-yl]carbamate
    —— tert-butyl N-[2-[2-[4-[2-(4-carbamoylanilino)-4-(propylamino)pyrimidin-5-yl]phenyl]ethylamino]-2-oxoethyl]carbamate —— C29H37N7O4
    tert-butyl N-[2-[2-[4-[2-(4-carbamoylanilino)-4-(propylamino)pyrimidin-5-yl]phenyl]ethylamino]-2-oxoethyl]carbamate
    —— tert-butyl N-[2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-2-oxoethyl]-N-ethylcarbamate —— C28H37N7O3
    tert-butyl N-[2-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-2-oxoethyl]-N-ethylcarbamate
    —— tert-butyl N-[3-[[2-(phthalazin-6-ylamino)-4-(propylamino)-1,4-dihydropyrimidine-5-carbonyl]amino]propyl]carbamate —— C24H34N8O3
    tert-butyl N-[3-[[2-(phthalazin-6-ylamino)-4-(propylamino)-1,4-dihydropyrimidine-5-carbonyl]amino]propyl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(ethylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C27H35N7O3
    tert-butyl N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(ethylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)pyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C30H43N9O4
    tert-butyl N-[(2S)-1-[5-[2-[[1-(2-methoxyethyl)pyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(1-methylpyrazol-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate —— C25H38N8O3
    tert-butyl N-methyl-N-[(2S)-1-[5-[2-[(1-methylpyrazol-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-(1,3-benzothiazol-6-ylamino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C28H37N7O3S
    tert-butyl N-[(2S)-1-[5-[2-(1,3-benzothiazol-6-ylamino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(5,6-dimethylpyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C28H41N7O3
    tert-butyl N-[(2S)-1-[5-[2-[(5,6-dimethylpyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[[(1S,3R)-3-[2-[2-(4-cyanoanilino)-4-propan-2-yloxypyrimidin-5-yl]ethynyl]cyclohexyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate —— C31H40N6O4
    tert-butyl N-[(2S)-1-[[(1S,3R)-3-[2-[2-(4-cyanoanilino)-4-propan-2-yloxypyrimidin-5-yl]ethynyl]cyclohexyl]amino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl N-[(2S)-1-[5-[4-(cyclopropylamino)-2-(3-fluoro-4-methoxyanilino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C28H37FN6O4
    tert-butyl N-[(2S)-1-[5-[4-(cyclopropylamino)-2-(3-fluoro-4-methoxyanilino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl (2S)-2-[5-[2-[[1-(2-methoxyethyl)pyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C31H43N9O4
    tert-butyl (2S)-2-[5-[2-[[1-(2-methoxyethyl)pyrazolo[3,4-b]pyridin-5-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate
    —— tert-butyl N-[(1S,3R)-3-[2-[4-(cyclopropylamino)-2-[(2-fluoropyridin-4-yl)amino]pyrimidin-5-yl]ethynyl]cyclohexyl]carbamate —— C25H31FN6O2
    tert-butyl N-[(1S,3R)-3-[2-[4-(cyclopropylamino)-2-[(2-fluoropyridin-4-yl)amino]pyrimidin-5-yl]ethynyl]cyclohexyl]carbamate
    —— tert-butyl N-[(2S)-1-[5-[2-[(5-chloropyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate —— C26H36ClN7O3
    tert-butyl N-[(2S)-1-[5-[2-[(5-chloropyridin-3-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-N-methylcarbamate
    —— tert-butyl (2S)-2-[5-[2-[(1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C29H39N9O3
    tert-butyl (2S)-2-[5-[2-[(1-methylpyrazolo[3,4-b]pyridin-5-yl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate
    —— tert-butyl (2S)-2-[5-[2-[[1-(2-methoxyethyl)indazol-6-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate —— C32H44N8O4
    tert-butyl (2S)-2-[5-[2-[[1-(2-methoxyethyl)indazol-6-yl]amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylcarbamoyl]pyrrolidine-1-carboxylate