(R)-5-methyl-1,4-oxazepane hydrochloride | 2694057-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: (R)-5-methyl-1,4-oxazepane hydrochloride
• 英文别名: (5R)-5-methyl-1,4-oxazepane hydrochloride；(5R)-5-methyl-1,4-oxazepane;hydrochloride
• CAS: 2694057-65-1
• 化学式: C₆H₁₃NO*ClH
• 分子量: 151.636
• InChiKey: WYSIGZNUVPDDKA-FYZOBXCZSA-N

反应信息

• 作为反应物：
  描述：

  7-(8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-ol 、 (R)-5-methyl-1,4-oxazepane hydrochloride 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以52 %的产率得到(R)-4-(7-(8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizine-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-5-methyl-1,4-oxazepane
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ET PROCÉDÉS D'UTILISATION

  摘要：

  The present disclosure provides compounds useful for the inhibition of KRAS. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

  公开号：

  WO2023018809A1