2-Adamantyl-dihydrogenphosphat | 74236-80-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2-Adamantyl-dihydrogenphosphat
• 英文别名: 2-Adamantyl dihydrogen phosphate
• CAS: 74236-80-9
• 化学式: C₁₀H₁₇O₄P
• 分子量: 232.216
• InChiKey: GHTUWYDIMIZEEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-Adamantyl-phosphorodichloridat 、 水 以67%的产率得到
  参考文献：
  名称：

  CREMLYN R. J.; ELLAN R. M.; AKHTAR N., PHOSPH. AND SULFUR, 1979, 7, NO 3, 257-264

  摘要：

  DOI：

文献信息

• DETERMINATION OF NUCLEASE ACTIVITY
  申请人：Zetatronics Limited

  公开号：EP1155143A1

  公开（公告）日：2001-11-21
• FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF
  申请人：SHANGHAI DE NOVO PHARMATECH CO., LTD.

  公开号：US20180022752A1

  公开（公告）日：2018-01-25

  This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.
• [EN] DETERMINATION OF NUCLEASE ACTIVITY<br/>[FR] DETERMINATION DE L'ACTIVITE DE NUCLEASE
  申请人：HARBRON STUART

  公开号：WO2000049172A1

  公开（公告）日：2000-08-24

  A method for detecting a nuclease enzyme is disclosed which comprises a method for detecting a nuclease enzyme comprising the steps: a) contacting said enzyme with a compound of formula RpX, wherein R is a 3' nucleosidyl derivative, p is a phospho radical, and X is an esterifiable moiety or, only if R is a 3' nicotinamide derivative, X is an esterifiable moiety or H, whereby ROH and pX are produced, and b) detecting said pX moiety or, only if R is a 3' nicotinamide derivative, detecting the pX moiety or the ROH moiety. In preferred embodiments the invention provides a method for detecting a nuclease enzyme that is free in solution, immobilised on a surface, or attached to a member of a specific binding pair. The method of the invention may thus be applied as a detection step in nucleic acid hybridisation assays, enzyme immunoassays and ligand:receptor binding assays. The invention provides a variety of methods for detecting the detectable moieties produced. These include fluorometric, colorimetric, and luminometric endpoints. Enzyme cycling and apoenzyme reactivation assays are also provided.