tetrasodium;phosphonato phosphate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 英文名称: tetrasodium;phosphonato phosphate
• 化学式: Na4O7P2
• 分子量: 265.9
• InChiKey: FQENQNTWSFEDLI-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  -15.32
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  136
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

代谢

焦磷酸在肠道中被水解成正磷酸。

Pyrophosphate is hydrolyzed to the orthophosphate in the gut.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

鉴定和使用：这种化学品是无色、透明的晶体或白色粉末或颗粒。它无味；在水中微溶；在酒精和氨中不溶。这种化学品用作清洁剂；油井钻探；水处理，奶酪乳化；作为一般的螯合剂，去除锈斑；作为一流体墨水擦除剂的一种成分，在金属电沉积中。它用于纺织品染色；羊毛的洗涤；缓冲剂；食品添加剂；洗涤剂增效剂；软化水和分散剂。人类暴露和毒性：碱性和刺激。摄入后可能会出现恶心、呕吐和腹泻。急性暴露的医疗报告显示轻至中度的皮肤和眼睛反应。动物研究：在老鼠饮食中添加高浓度的焦磷酸四钠会导致肾脏损害。这种化学品对鸡胚胎有致畸作用。急性研究表明，直接接触会严重刺激家兔眼睛并造成角膜损伤，并且可能对皮肤有刺激性。这种化学品可以被认为是中度毒性，通过摄入可能引起代谢性酸中毒和低钙血症。

IDENTIFICATION AND USE: This chemical is a colorless, transparent crystals or white powder or granules. It is odorless; slightly soluble in water; insoluble in alcohol and ammonia. This chemical is used as a cleaning compound; oil well drilling; water treatment, cheese emulsification; as a general sequestering agent, to remove rust stains; as am ingredient of one fluid ink eradicators, in electrodeposition of metals. It is used in textile dyeing; scouring of wool; buffer; food additive; detergent builder; water softener and dispersant. HUMAN EXPOSURE AND TOXICITY: Alkaline and irritating. Nausea, vomiting and diarrhea are probable after ingestion. Medical reports of acute exposures show mild to moderate dermal and ocular responses. ANIMAL STUDIES: Tetrasodium pyrophosphate when added to the diets of rats in high concentrations it caused kidney damage. This chemical caused teratogenic effects in chicken embryos. Acute studies show that direct contact causes severe irritation and corneal injury in the rabbit eye and that it may be irritating to skin. This chemical can be considered moderately toxic on ingestion, inducing metabolic acidosis, and hypocalcemia.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入灰尘和摄入的方式被身体吸收。

The substance can be absorbed into the body by inhalation of dust and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，吞食，皮肤和/或眼睛接触

inhalation, ingestion, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼睛、皮肤、鼻子、喉咙刺激；皮炎

irritation eyes, skin, nose, throat; dermatitis

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 吸入症状

咳嗽。喉咙痛。

Cough. Sore throat.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

反应信息

• 作为反应物：
  描述：

  无水氯化钙 、 tetrasodium;phosphonato phosphate 生成 Calcium sodium pyrophosphate tetrahydrate
  参考文献：
  名称：

  Process for gelling aqueous polyol suspensions and resulting gel

  摘要：

  本发明涉及一种新型部分脱水非晶态钙钠焦磷酸盐及其制备方法。此外，本发明还涉及使用这些化合物使一些多元醇的水溶液凝胶化的过程，以及由此获得的凝胶。

  公开号：

  US03985675A1
• 作为产物：
  描述：

  tetrasodium;1-[5-[[[[5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonatooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]-4H-pyridine-3-carboximidate 、 Sodium phosphate, tribasic- 、 硫酸 、 disodium;hydrogen phosphate 在 disodium;hydrogen phosphate 作用下， 生成 tetrasodium;phosphonato phosphate
  参考文献：
  名称：

  Production of ingredients for detergents and soap powders from alkali

  摘要：

  从碱金属正磷酸盐中生产碱金属聚磷酸盐和/或聚焦磷酸盐的过程包括用硫酸使该正磷酸盐酸化，然后要么(a)将反应混合物加热以产生所需的产物，并从反应混合物中回收所述产物，要么(b)从反应混合物中分离出中间体，并加热该中间体以形成所需的产物。这些产物适用于纳入洗涤剂和肥皂粉中。

  公开号：

  US04707344A1

文献信息

• Method for producing nucleoside-5'-phosphate ester
  申请人：——

  公开号：US20020004590A1

  公开（公告）日：2002-01-10

  A method for producing nucleoside-5′-phosphate esters inexpensively and in high yields by phosphorylating a nucleoside with a phospahte group donor using an acid phosphatase having an increased affinity for the nucleoside and/or an increased temperature stability at a pH of pH 3.0 to 5.5, to produce a nucleoside-5′-phosphate ester. Mutant acid phosphatases having increased affinty for nucleosides and/or an enhanced temperature stability are also provided.

  一种制备核苷酸5'-磷酸酯的方法，通过使用具有对核苷酸增加亲和力和/或在pH 3.0至5.5的条件下具有增强温度稳定性的酸性磷酸酶，用磷酸供体对核苷酸进行磷酸化，以低成本高产率地制备核苷酸5'-磷酸酯。还提供了具有增强核苷酸亲和力和/或增强温度稳定性的突变酸性磷酸酶。
• Enzymes
  申请人：Chawla K. Narinder

  公开号：US20050118594A1

  公开（公告）日：2005-06-02

  Various embodiments of the invention provide human enzymes (ENZM) and polynucleotides which identify and encode-ENZM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ENZM.

  本发明的各种实施例提供了人类酶（ENZM）和识别并编码ENZM的多核苷酸。本发明的实施例还提供表达载体、宿主细胞、抗体、激动剂和拮抗剂。其他实施例提供了诊断、治疗或预防与ENZM异常表达相关的疾病的方法。
• Water-soluble partially saponified copolymers based on vinyl acetate and
  申请人：BASF Aktiengesellschaft

  公开号：US04452949A1

  公开（公告）日：1984-06-05

  By emulsion polymerization of vinyl acetate, methylacrylate, acrylic acid, monoolefinically unsaturated sulfoalkyl esters or amides and vinyl sulfonate and partial saponification of the resultant copolymer emulsion, an aqueous solution of a copolymer is obtained which greatly delays the polymerization of styrene in aqueous media.

  通过乙酸乙烯酯、甲基丙烯酸酯、丙烯酸、单烯基不饱和磺酸酯或酰胺和乙烯磺酸酯的乳液聚合，以及对得到的共聚物乳液进行部分皂化，可以得到一种共聚物的水溶液，该水溶液可以极大地延缓苯乙烯在水介质中的聚合。
• Continuous process for phosphorylating starch
  申请人：National Starch and Chemical Corporation

  公开号：US04216310A1

  公开（公告）日：1980-08-05

  Starch is phosphorylated by a virtually pollution-free, continuous process whereby an aqueous reagent solution of a tripolyphosphate, orthophosphate or pyrophosphate salt or a mixture thereof is sprayed onto a moist starch cake on a rotary vacuum filter in an amount sufficient to achieve efficient impregnation of the starch cake without losing significant levels of salt to the effluent. In a preferred embodiment, the reagent solution contains alkali metal tripolyphosphate salt and is obtained by diluting a concentrated solution thereof. The thus-impregnated starch is subsequently dried and heat-reacted by known procedures to produce an orthophosphate starch monoester.

  淀粉可以通过一种几乎无污染的连续过程进行磷酸化，该过程中，将三聚磷酸盐、正磷酸盐或焦磷酸盐的水溶性试剂溶液或其混合物喷洒到旋转真空过滤器上的湿淀粉蛋糕上，以达到高效浸渍淀粉蛋糕的目的，同时不会使盐的水平显著降低。在一种优选实施方式中，试剂溶液含有碱金属三聚磷酸盐，并通过稀释浓缩溶液获得。随后，经过已知的程序对浸渍的淀粉进行干燥和热反应，以产生正磷酸酯淀粉。
• .alpha.-N-Acetyl-L-phenylalanyl-L-arginine ethyl ester
  申请人：Bayer Aktiengesellschaft

  公开号：US04234477A1

  公开（公告）日：1980-11-18

  The new compound acetylphenylalanyl-arginine ethyl ester (Ac-Phe-Arg OEt) and its acid addition salts are used in the diagnostic determination of the content of Kallikrein. In view of the role of Kallikrein in regulating blood pressure or the renal function, the reliable determination of small amounts of Kallikrein such as occur in urine, saliva or glands is important but has been difficult to achieve. Ac-Phe-Arg OEt and its esters provide a substrate for use in such determinations and allow a significant improvement in accuracy.

  新合成的乙酰苯丙氨酰-精氨酸乙酯（Ac-Phe-Arg OEt）及其酸盐加合物用于诊断测定卡利肯酶的含量。由于卡利肯酶在调节血压或肾功能方面的作用，可靠地测定尿液、唾液或腺体等中微量卡利肯酶的含量非常重要，但一直难以实现。Ac-Phe-Arg OEt及其酯类提供了用于这种测定的底物，并允许显着提高准确性。