| 1246341-59-2

• CAS: 1246341-59-2
• 化学式: C₃₀H₃₆Cl₂Fe₂N₆O₁₁S₂
• 分子量: 903.381
• InChiKey: ITFPJBJSXQAOSU-UHFFFAOYSA-J

反应信息

• 作为产物：
  描述：

  ferrous(II) sulfate heptahydrate 、 1-(bispyridin-2-ylmethylamino)-3-chloropropan-2-ol 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Highly efficient synthetic iron-dependent nucleases activate both intrinsic and extrinsic apoptotic death pathways in leukemia cancer cells

  摘要：

  The nuclease activity and the cytotoxicity toward human leukemia cancer cells of iron complexes, [Fe(HPClNOL) Cl-2]NO3 (1), [Cl(HPClNOL)Fe(mu-O)Fe(HPClNOL)Cl]Cl-2 center dot 2H(2)O (2), and [(SO4)(HPCINOL)Fe(mu-O)Fe(HPCINOL)(SO4)]center dot 6H(2)O (3) (HPCINOL = 1-(bis-pyridin-2-ylmethyl-amino)-3-chloropropan-2-ol), were investigated. Each complex was able to promote plasmid DNA cleavage and change the supercoiled form of the plasmid to circular and linear ones. Kinetic data revealed that (1), (2) and (3) increase the rate of DNA hydrolysis about 278, 192 and 339 million-fold, respectively. The activity of the complexes was inhibited by distamycin, indicating that they interact with the minor groove of the DNA. The cytotoxic activity of the complexes toward U937, HL-60, Jukart and THP-1 leukemia cancer cells was studied employing 3-(4,5-dimethythiazol-2-y1)-2,5-diphenyl tetrazolium bromide (MTT), fluorescence and electronic transmission microscopies, flow cytometry and a cytochrome C release assay. Compound (2) has the highest activity toward cancer cells and is the least toxic for normal ones (i.e. peripheral blood mononuclear cells (PBMCs)). In contrast, compound (1) is the least active toward cancer cells but displays the highest toxicity toward normal cells. Transmission electronic microscopy indicates that cell death shows features typical of apoptotic cells, which was confirmed using the annexin V-FITC/PI (fluorescein isothiocyanate/propidium iodide) assay. Furthermore, our data demonstrate that at an early stage during the treatment with complex (2) mitochondria lose their transmembrane potential, resulting in cytochrome C release. A quantification of caspases 3,9 (intrinsic apoptosis pathway) and caspase 8 (extrinsic apoptosis pathway) indicated that both the intrinsic (via mitochondria) and extrinsic (via death receptors) pathways are involved in the apoptotic stimuli. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.07.019
• 作为试剂：
  描述：

  环己烷 在 C₃₀H₃₆Cl₂Fe₂N₆O₁₁S₂ 、 双氧水 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 环己基过氧化氢化物 、 环己醇
  参考文献：
  名称：

  （μ-氧代）二铁配合物的性质及其对环己烷氧化的催化活性

  摘要：

  我们在这里报告通过FeSO4•7H2 O和FeCl3•6H2 O与1-（双-吡啶-2-基甲基-氨基）-3-氯丙烷-2-的反应获得的两种双核μ-氧代铁化合物的合成和表征醇（L5），生成化合物[（SO4）（L5）Fe（μ-O）Fe（L5）（SO4）]•6H2O，1和[Cl（L5）Fe（μ-O）Fe（ L5）Cl] Cl2•2H2O，2.两种化合物的电子光谱仅在UV范围内显示吸收带。电化学分析表明，化合物1还原后，双核单元比化合物2更稳定。而Mossbauer光谱显示，单齿配体（硫酸盐和氯化物）对为1和2确定的Mossbauer参数具有重要影响。在四极分裂值上。研究了这两种化合物在环己烷氧化反应中的催化剂，使用H2O2和t-BuOOH作为氧化剂，底物：氧化剂：催化剂的比例为1000：1000：1。在此过程中形成了环己醇，环己酮，环己基氢过氧化物，叔丁基环己基过氧化物和己二酸。实验表明，在促进环己

  DOI：

  10.1590/s0103-50532010000400004