geranylgeranyl diphosphate synthase | 9032-58-0

• 分子结构分类: 转移酶 - 转移烷基或芳基（甲基除外） - 转移除甲基以外的烷基或芳基（有子类）
• 英文名称: geranylgeranyl diphosphate synthase
• 英文别名: geranylgeranyl-diphosphate synthase；geranylgeranyl pyrophosphate synthetase；geranylgeranyl-PP synthetase；farnesyltransferase；geranylgeranyl pyrophosphate synthase；farnesyltranstransferase (obsolete)
• CAS: 9032-58-0

反应信息

• 作为试剂：
  描述：

  isopentenyl pyrophosphate 、 DMAPP 在 geranylgeranyl diphosphate synthase 作用下， 生成 geranylgeranyl diphosphate
  参考文献：
  名称：

  Identification of CDP-Archaeol Synthase, a Missing Link of Ether Lipid Biosynthesis in Archaea

  摘要：

  Archaeal membrane lipid composition is distinct from Bacteria and Eukarya, consisting of isoprenoid chains etherified to the glycerol carbons. Biosynthesis of these lipids is poorly understood. Here we identify and characterize the archaeal membrane protein CDP-archaeol synthase (CarS) that catalyzes the transfer of the nucleotide to its specific archaeal lipid substrate, leading to the formation of a CDP-activated precursor (CDP-archaeol) to which polar head groups are attached. The discovery of CarS enabled reconstitution of the entire archaeal lipid biosynthesis pathway in vitro, starting from simple isoprenoid building blocks and using a set of five purified enzymes. The cell free synthetic strategy for archaeal lipids we describe opens opportunity for studies of archaeal lipid biochemistry. Additionally, insights into archaeal lipid biosynthesis reported here allow addressing the evolutionary hypothesis of the lipid divide between Archaea and Bacteria.

  DOI：

  10.1016/j.chembiol.2014.07.022