erythravine | 19373-79-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 刺桐生物碱
• 英文名称: erythravine
• 英文别名: (2R,13bS)-11,12-dimethoxy-2,6,8,9-tetrahydro-1H-indolo[7a,1-a]isoquinolin-2-ol
• CAS: 19373-79-6
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: JEBFJSHKHYDVNP-KSSFIOAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  刺桐特灵碱 在 盐酸 、 硫酸 作用下， 生成 erythravine
  参考文献：
  名称：

  Sarragiotto, Maria Helena; Costa, Paulo A. da; Marsaioli, Anita J., Heterocycles, 1984, vol. 22, # 3, p. 453 - 456

  摘要：

  DOI：

文献信息

• Total synthesis of (±)-erythravine based on ring closing dienyne metathesis
  作者：Hironori Fukumoto、Tomoyuki Esumi、Jun Ishihara、Susumi Hatakeyama

  DOI：10.1016/j.tetlet.2003.09.059

  日期：2003.10

  The first total synthesis of (±)-erythravine was achieved in thirteen steps from 3,4-dimethoxyphenethylamine using ring closing dienyne metathesis as the key step.

  使用闭环二烯炔复分解为关键步骤，由3,4-二甲氧基苯乙胺在13个步骤中完成了（±）-赤藓烷的第一个全合成。
• PHARMACEUTICAL COMPOSITIONS CONTAINING ERYTHRINE MULUNGU DERIVATIVES AND PROCESSES FOR THEIR PRODUCTION
  申请人：Universidade Estadual Paulista Julio De Mesquita Filho-UNESP

  公开号：EP1948162B1

  公开（公告）日：2013-05-22
• Pharmaceutical Compositions Containing Erythrina Mulungu Derivatives, Processes for their Production and Uses Thereof
  申请人：Bolzani Vanderlan da silva

  公开号：US20080227801A1

  公开（公告）日：2008-09-18

  The present invention provides the use of molecules for cholinergic serotonergic and/or gabaergic system models, revealing pharmaceutical compositions comprising 11-OH-erythravine, erythravine, erythrartine, pharmaceutically acceptable isotherals, salts, byproducts and/or solvates thereof, optionally containing other Erythrine byproducts, for the treatment of anxiety disorders; processes for obtaining said pharmaceutical compositions are also revealed.
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING ERYTHRINE MULUNGU DERIVATIVES AND PROCESSES FOR THEIR PRODUCTION<br/>[FR] COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES D'ERYTHRINE MULUNGU ET LEURS PROCEDES DE PRODUCTION
  申请人：UNIV ESTADUAL PAULISTA JULIO D

  公开号：WO2007045060A1

  公开（公告）日：2007-04-26

  (EN) The present invention provides the use of molecules for cholinergic serotonergic and/or gabaergic system models, revealing pharmaceutical compositions comprising 11-OH-erythravine, erythravine, erythrartine, pharmaceutically acceptable isotherals, salts, byproducts and/or solvates thereof, optionally containing other Erythrine byproducts, for the treatment of anxiety disorders; processes for obtaining said pharmaceutical compositions(FR) L'invention concerne l'utilisation de molécules destinées à des modèles de systèmes cholinergiques, sérotonergiques et/ou gabaergiques; la mise en évidence de compositions pharmaceutiques comprenant 11-OH-érythravine, érythravine, érythrartine, des isothérals pharmaceutiquement acceptables, des sels, des sous-produits et/ou des solvates ceux-ci contenant éventuellement d'autres sous-produits d'érythrine permettant de traiter les troubles de l'anxiété; et des procédés permettant d'obtenir lesdites compositions pharmaceutiques.
• Sarragiotto, Maria Helena; Costa, Paulo A. da; Marsaioli, Anita J., Heterocycles, 1984, vol. 22, # 3, p. 453 - 456
  作者：Sarragiotto, Maria Helena、Costa, Paulo A. da、Marsaioli, Anita J.

  DOI：——

  日期：——