5-chloro-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy))))phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene | 1402581-14-9

• 英文名称: 5-chloro-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy))))phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene
• CAS: 1402581-14-9
• 化学式: C₃₀H₂₈BClF₂N₂O₄
• 分子量: 564.824
• InChiKey: FACYTQDKWBPARZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  5-chloro-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy))))phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene 、 二甲基吡啶胺 在 sodium hydride 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以57%的产率得到5-N-(2-picolyl)amine-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy)))) phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene
  参考文献：
  名称：

  A BODIPY derivative as a colorimetric, near-infrared and turn-on chemosensor for Cu2+

  摘要：

  A new colorimetric and near-infrared (NIR) fluorescent chemosensor (1) for Cu2+ based on BODIPY has been synthesized and investigated in this work. 1 Displays a high selectivity for Cu2+ with about 250-fold enhancement in fluorescence emission intensity and micromolar sensitivity (K-d = 2.8 +/- 0.3 mu M) in comparison with alkali and alkaline earth metal ions (Na+, K+, Mg2+, Ca2+) and other metal ions (Ba2+, Zn2+, Cd2+, Fe2+, Pb2+, Ni2+, Co2+, Ag+) upon excitation at 635 nm in CH3CN. Meanwhile, the distinct color changes and rapid switch-on fluorescence also provide 1 as colorimetric senor for Cu2+. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.04.091
• 作为产物：
  描述：

  3,5-dichloro-8-(4-tolyl) BODIPY 、 2-(2-(2-(4-ethynylphenoxy)ethoxy)ethoxy)ethanol 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以87%的产率得到5-chloro-4,4-difluoro-3-(4-(hydroxy(ethyloxy(ethyloxy(ethyloxy))))phenylethynyl)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene
  参考文献：
  名称：

  A BODIPY derivative as a colorimetric, near-infrared and turn-on chemosensor for Cu2+

  摘要：

  A new colorimetric and near-infrared (NIR) fluorescent chemosensor (1) for Cu2+ based on BODIPY has been synthesized and investigated in this work. 1 Displays a high selectivity for Cu2+ with about 250-fold enhancement in fluorescence emission intensity and micromolar sensitivity (K-d = 2.8 +/- 0.3 mu M) in comparison with alkali and alkaline earth metal ions (Na+, K+, Mg2+, Ca2+) and other metal ions (Ba2+, Zn2+, Cd2+, Fe2+, Pb2+, Ni2+, Co2+, Ag+) upon excitation at 635 nm in CH3CN. Meanwhile, the distinct color changes and rapid switch-on fluorescence also provide 1 as colorimetric senor for Cu2+. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.04.091