d'hydroxy-2 teramethyl-4,4,5,5-dioxaphospholane-1,2,3 | 58954-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧磷杂环戊烷
• 英文名称: d'hydroxy-2 teramethyl-4,4,5,5-dioxaphospholane-1,2,3
• 英文别名: 4,4,5,5-tetramethyl-[1,3,2]dioxaphospholane 2-oxide；4,4,5,5-tetramethyl-[1,3,2]dioxaphospholan-2-ol；O,O'-phosphonoyl-pinacol；pinacol phosphonate；4,4,5,5-Tetramethyl-1,3,2-dioxaphospholan-2-OL；2-hydroxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane
• CAS: 58954-06-6
• 化学式: C₆H₁₃O₃P
• 分子量: 164.141
• InChiKey: FHVCUEQIXRYFHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  d'hydroxy-2 teramethyl-4,4,5,5-dioxaphospholane-1,2,3 在 水 作用下， 生成 1,2-diphenyl-2-(4,4,5,5-tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yloxy)-ethanone
  参考文献：
  名称：

  Ovchinnikov, V. V.; Safina, Yu. G.; Cherkasov, R. A., Journal of general chemistry of the USSR, 1988, vol. 58, # 9, p. 1841 - 1852

  摘要：

  DOI：
• 作为产物：
  描述：

  频哪醇 在 三氯化磷 作用下， 生成 d'hydroxy-2 teramethyl-4,4,5,5-dioxaphospholane-1,2,3
  参考文献：
  名称：

  钯催化的环丙烯的加氢磷酸化和加氢膦酰化。

  摘要：

  已经开发了跨环丙烯双键的新型的过渡金属催化的PH实体加成。该转化允许以良好的产率和高度的非对映选择性温和而有效地制备含磷的环丙烷。

  DOI：

  10.1021/ol8011138

文献信息

• METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20190263847A1

  公开（公告）日：2019-08-29

  Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R 1 represents OR 3 or R 3 , R 2 represents OR 4 or R 4 , and R 3 and R 4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): R 5 —C≡CH  (2) [In formula (2), R 5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.] to produce the phosphorus alkenyl compound presented by at least any of the following formulas (3a) or (3b): [In formulas (3a) and (3b), R 1 and R 2 have the same meaning as defined in formula (1), and R 5 has the same meaning as defined in formula (2).], In which the compound represented by formula (1) is reacted with the compound represented by formula (2) using a transition metal catalyst, and a phosphorus oxo acid compound having an intramolecular P—H bond.

  提供的是一种生产烯基磷化合物的方法，该方法即使使用的催化剂量比传统方法少，也能高效地生产烯基磷化合物，而且能够在更大的反应规模下保持催化活性，以高收率生产烯基磷化合物，并且还可以在传统的批量反应器或连续反应器中进行工业规模的量产合成。 生产烯基磷化合物的方法包括以下步骤： 将以下式（1）所表示的化合物与以下式（2）所表示的化合物反应： 式（1）中，R1代表OR3或R3，R2代表OR4或R4，R3和R4例如各自独立地代表取代或未取代的烷基基团。 式（2）中，R5例如代表氢原子，或代表取代或未取代的烷基基团。 从而产生至少以下任一式（3a）或（3b）所表示的磷烯烃化合物： 式（3a）和（3b）中，R1和R2的含义与式（1）中定义的相同，R5的含义与式（2）中定义的相同。 其中，使用过渡金属催化剂和具有分子内P-H键的磷氧酸化合物使式（1）所表示的化合物与式（2）所表示的化合物反应。
• Method for producing alkenyl phosphorus compound
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US10479809B2

  公开（公告）日：2019-11-19

  Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R1 represents OR3 or R3, R2 represents OR4 or R4, and R3 and R4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): [In formula (2), R5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.] to produce the phosphorus alkenyl compound presented by at least any of the following formulas (3a) or (3b): [In formulas (3a) and (3b), R1 and R2 have the same meaning as defined in formula (1), and R5 has the same meaning as defined in formula (2).], In which the compound represented by formula (1) is reacted with the compound represented by formula (2) using a transition metal catalyst, and a phosphorus oxo acid compound having an intramolecular P—H bond.

  本发明提供了一种生产烯基磷化合物的方法，与传统方法相比，该方法即使使用较少量的催化剂也能高效生产烯基磷化合物，而且即使在较大的反应规模下也能保持催化活性以高产率生产烯基磷化合物，该方法还可用于使用传统的间歇反应器或连续反应器进行工业规模的定量合成。 一种生产烯基磷化合物的方法，包括 使下式（1）代表的化合物反应的步骤： 式（1）中，R1 代表 OR3 或 R3，R2 代表 OR4 或 R4，R3 和 R4 例如各自独立地代表取代或未取代的烷基。 与下式（2）所代表的化合物： 式（2）中，R5 代表氢原子或取代或未取代的烷基。 生成至少由以下任何式子（3a）或（3b）表示的磷烯基化合物： [在式 (3a) 和 (3b) 中，R1 和 R2 与式 (1) 所定义的含义相同，R5 与式 (2) 所定义的含义相同、］ 其中，使用过渡金属催化剂使式（1）代表的化合物与式（2）代表的化合物以及具有分子内 P-H 键的氧化磷化合物反应。
• Manouni, D. El; Leroux, Y.; Burgada, R., Phosphorus, Sulfur and Silicon and the Related Elements, 1989, vol. 42, p. 73 - 84
  作者：Manouni, D. El、Leroux, Y.、Burgada, R.

  DOI：——

  日期：——
• Francke, R.; Heine, J.; Roeschenthaler, G.-V., Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 49/50, p. 377 - 380
  作者：Francke, R.、Heine, J.、Roeschenthaler, G.-V.

  DOI：——

  日期：——
• Bailly, Theodorine; Burgada, Ramon, Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 63, # 1/2, p. 33 - 43
  作者：Bailly, Theodorine、Burgada, Ramon

  DOI：——

  日期：——