2-(Deuteriomethyl)-1,3,5-trinitrobenzene | 105225-06-7

• 英文名称: 2-(Deuteriomethyl)-1,3,5-trinitrobenzene
• CAS: 105225-06-7
• 化学式: C₇H₅N₃O₆
• 分子量: 228.125
• InChiKey: SPSSULHKWOKEEL-MICDWDOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4,6-三硝基甲苯 在 氘氧化钠 、 氘代盐酸 作用下， 以 氘代四氢呋喃 、 重水 为溶剂， 生成 2-(Deuteriomethyl)-1,3,5-trinitrobenzene
  参考文献：
  名称：

  Speciation of the Products of and Establishing the Role of Water in the Reaction of TNT with Hydroxide and Amines: Structure, Kinetics, and Computational Results

  摘要：

  The reaction of trinitrotoluene (TNT) with bases has been investigated by NMR and visible spectroscopy methods. Hydroxide ion was found to react in one of two ways, either by deprotonation of the methyl group or by nucleophilic attack on the aromatic ring to form a sigma adduct. The rate of each mode of reaction depends upon the polarity of the solvent. In tetrahydrofuran (THF), a adduct formation is rapid and the long-term equilibrium product is deprotonation of the methyl group. When the solvent is methanol (MeOH), the two reactions have similar rates and the sigma adduct becomes the majority product. Amines were found to be ineffective in directly deprotonating TNT or in forming sigma adducts. Rather, the amines react with ambient water to generate hydroxide ion, which then reacts with TNT. The solvent choice and water content are crucial to understanding the reactivity of bases with TNT. To assist in the interpretation of the experimental results, computational analysis was performed at the B3LYP/6-311+G**//HF/6-311+G** level to determine the thermodynamics of the reactions of TNT. The SM8 implicit solvation model was applied to converged geometries and suggested a strong solvation effect upon product formation. Thermodynamic analysis suggested a significant preference of alkoxide or hydroxide attack versus amine attack in any modeled dielectric, consistent with the experimental observations.

  DOI：

  10.1021/jp408992n