[Hydroxy(pentadecoxy)phosphoryl] hydrogen carbonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [Hydroxy(pentadecoxy)phosphoryl] hydrogen carbonate
• 英文别名: [hydroxy(pentadecoxy)phosphoryl] hydrogen carbonate
• 化学式: C₁₆H₃₃O₆P
• 分子量: 352.4
• InChiKey: DQRYODCPQOXKQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Method for preparing an outer surface of a planar waveguide to be capable of binding target samples along a plurality of predetermined lines and a planar waveguide
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2757374A1

  公开（公告）日：2014-07-23

  A method for preparing the outer surface (11) of a planar waveguide (1) for binding target samples along a plurality of predetermined lines (4). The method comprises sequentially applying at least one plurality of linker molecules (2, 5) to the outer surface (11) of a planar waveguide (1) adapted for attachment of a head group (21) of a linker molecule (2) to the outer surface (11) to form an individual layer of linker molecules (2, 5) with individual layers formed one above the other starting from the outer surface (11) of the planar waveguide (1). Each linker molecule (2, 5) comprises a functional group (22, 52) and the head group (21, 51) which is capable of attaching to the outer surface (11) of the planar waveguide (1) or to the functional groups (22) of the preceding layer of linker molecules (2). The functional groups of the uppermost layer are bound to photo-labile protecting groups (3). Exposing those groups (3) of the uppermost layer arranged along a plurality of predetermined lines (4) to light of a predetermined wavelength removes the exposed photo-labile groups (3) from the functional groups (52) to make these functional groups (52) capable of attaching a complementary functional group of a further molecule.

  一种制备平面波导（1）外表面（11）的方法，用于沿多条预定线（4）结合目标样品。该方法包括在平面波导（1）的外表面（11）上依次施加至少一个多个连接体分子（2，5），以将连接体分子（2）的头部基团（21）附着在外表面（11）上，从而形成单个连接体分子（2，5）层，单个层从平面波导（1）的外表面（11）开始一个接一个地形成。每个连接剂分子（2，5）都包括一个官能团（22，52）和头部基团（21，51），它们能够附着在平面波导（1）的外表面（11）或前一层连接剂分子（2）的官能团（22）上。最上层的官能团与光敏保护基团（3）结合。将最上层沿多条预定线（4）排列的那些基团（3）暴露在预定波长的光下，可从官能团（52）上去除暴露的光敏基团（3），使这些官能团（52）能够连接另一个分子的互补官能团。
• METHOD FOR PREPARING AN OUTER SURFACE OF A PLANAR WAVEGUIDE TO BE CAPABLE OF BINDING TARGET SAMPLES ALONG A PLURALITY OF PREDETERMINED LINES AND A PLANAR WAVEGUIDE
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2946210B1

  公开（公告）日：2018-04-11
• Method For Preparing An Outer Surface Of A Planar Waveguide To Be Capable Of Binding Target Samples Along A Plurality Of Predeterminded Lines And A Planar Waveguide
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20150338579A1

  公开（公告）日：2015-11-26

  According to the invention there is provided a method for preparing the outer surface ( 11 ) of the planar waveguide ( 1 ) for binding target samples along the plurality of predetermined lines ( 4 ). The method comprises the following steps. Providing a planar waveguide ( 1 ) with an outer surface ( 11 ) adapted for attachment of a head group ( 21 ) of a linker molecule ( 2 ) to the outer surface ( 11 ). Sequentially applying at least one plurality of linker molecules ( 2, 5 ) to the outer surface ( 11 ). Each plurality of the at least one plurality of linker molecules ( 2, 5 ) assembles to form an individual layer of linker molecules ( 2, 5 ) with individual layers formed one above the other starting from the outer surface ( 11 ) of the planar waveguide ( 1 ). Each linker molecule ( 2, 5 ) comprises a functional group ( 22, 52 ) and the head group ( 21, 51 ) which is capable of attaching to the outer surface ( 11 ) of the planar waveguide ( 1 ) or to the functional groups ( 22 ) of the preceding layer of linker molecules ( 2 ). The functional groups ( 52 ) of the plurality of linker molecules ( 5; 2 ) of the uppermost layer are bound to photo-labile protecting groups ( 3 ) so that each functional group ( 52 ) bound to a said photo-labile protecting group ( 3 ) is incapable of attaching a complementary functional group of a further molecule. Exposing those photo-labile protecting groups ( 3 ) of the uppermost layer arranged along a plurality of predetermined lines ( 4 ) to light of a predetermined wavelength to remove the exposed photo-labile protecting groups ( 3 ) from the functional groups ( 52 ) to make these functional groups ( 52 ) capable of attaching a complementary functional group of a further molecule.
• US9405069B2
  申请人：——

  公开号：US9405069B2

  公开（公告）日：2016-08-02