(2,2-Dimethyl-3-oxopropoxy)methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: (2,2-Dimethyl-3-oxopropoxy)methyl dihydrogen phosphate
• 英文别名: (2,2-dimethyl-3-oxopropoxy)methyl dihydrogen phosphate
• 化学式: C₆H₁₃O₆P
• 分子量: 212.14
• InChiKey: FKOHCTGTZBXHCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PEPTIDE AND PEPTIDE MIMETIC BINDING ANTAGONISTS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE<br/>[FR] ANTAGONISTES DE LIAISON PEPTIDIQUE ET MIMÉTIQUE DE PEPTIDE DE DOMAINE POLO BOX DOMAIN DE KINASE 1 DE TYPE POLO ET MÉTHODES D'UTILISATION
  申请人：US HEALTH

  公开号：WO2014153101A2

  公开（公告）日：2014-09-25

  The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.