Bis(2,2-dioxo-1,3,2,4-dioxathiathalletan-4-yl) sulfate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属氧阴离子化合物
• 英文名称: Bis(2,2-dioxo-1,3,2,4-dioxathiathalletan-4-yl) sulfate
• 化学式: O₁₂S₃Tl₂
• 分子量: 697.0
• InChiKey: BXBMHLIYMZRCNK-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  -4.78
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  266
• 氢给体数：
  0
• 氢受体数：
  12

ADMET

毒理性

• 副作用

神经毒素 - 感觉运动 职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学物质在职业环境中可能对肾脏有毒。

Neurotoxin - Sensorimotor Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 医疗监测

以下医疗程序应提供给每个可能接触到潜在有害水平的铊及其化合物的员工：初次医疗检查：进行全面的历史和体格检查：目的是为了检测可能使暴露员工处于增加风险现状的现有条件，并为未来的健康监测建立基准。应强调对眼睛、神经系统、肺、肝、肾、胃肠道的检查和体毛。尿液分析：由于在接触铊的人中已经观察到肾脏损伤，因此应获得尿液分析，至少包括比重、白蛋白、葡萄糖和对离心沉淀物的显微镜检查。定期医疗检查：这些医疗检查应每年重复进行。铊及其化合物

The following medical procedures should be made available to each employee who is exposed to ... thallium /and thallium/ compounds at potentially hazardous levels: Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the eyes, nervous system, lung, liver, kidneys, gastrointestinal tract, and body hair should be stressed. Urinalysis: Since kidney damage has been observed in humans exposed to thallium, a urinalysis should be obtained to include at a minimum specific gravity, albumin, glucose, and a microscopic /examination/ on centrifuged sediment. Periodic Medical Examination: These medical examinations should be repeated on an annual basis. /Thallium and thallium compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

铊是一种皮肤致敏剂和累积性毒物，可通过摄入、吸入或皮肤吸收而有毒性。/可溶性铊化合物/

Thallium is a skin sensitizer and cumulative poison which is toxic by ingestion, inhalation or skin absorption. /Soluble thallium compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

铥的分布情况在一名患者体内57种尸检组织中得到了确定，包括血液，这名患者口服了500毫居里的铥硝酸盐（TlNO3），随后又服用了直到225毫克为止的45毫克剂量的铥(I)硫酸盐（Tl2SO4）……。血液中在2小时内迅速上升到摄入放射性同位素的3%的水平……降至1.6%。铥在特定部位有一定的定位，发现顺序依次为头皮毛发、肾脏、心肌、原发骨肿瘤和脾脏，之后是肾上腺髓质、来自肺的骨肿瘤、胰腺、头皮皮肤和肝脏、肋骨骨髓、甲状腺、肾上腺皮质和垂体。……在注射了23微克TlNO3的大鼠中发现了不同的分布情况。……给药后2天，肾脏含有最高的浓度，其次是肠道、性腺和胰腺。…这些铥定位的差异表明在将动物实验结果应用于人类时需要谨慎。

THE DISTRIBUTION OF THALLIUM WAS DETERMINED IN 57 AUTOPSIED TISSUES, INCL BLOOD, OF A PATIENT WHO HAD BEEN ORALLY ADMIN 500 mCi THALLOUS NITRATE (TlNO3) FOLLOWED BY ... 45 MG DOSES ... THALLIUM(I) SULFATE (Tl2SO4) ... UNTIL 225 MG HAD BEEN GIVEN. THE BLOOD SHOWED A RAPID RISE WITHIN 2 HR TO A LEVEL OF 3% OF THE ADMIN RADIOISOTOPE ... TO 1.6%. SOME SPECIFIC LOCALIZATION OF THALLIUM ... WAS FOUND IN THE SCALP HAIR, KIDNEYS, HEART MUSCLE, PRIMARY BONE TUMOR, AND SPLEEN, IN THAT DECREASING ORDER. ... CLOSELY FOLLOWED BY ADRENAL MEDULLA, BONE TUMOR FROM LUNG, PANCREAS, SCALP SKIN, AND LIVER, RIB MARROW, THYROID, ADRENAL CORTEX, AND PITUITARY. ... A DIFFERENT DISTRIBUTION PICTURE WAS FOUND IN THE RAT ... INJECTED WITH 23 UG TlNO3. ... 2 DAYS AFTER DOSING, THE KIDNEYS CONTAINED THE HIGHEST CONCN FOLLOWED BY THE GUT, GONADS, AND PANCREAS. ... THESE DIFFERENCES IN LOCALIZATION OF THALLIUM SUGGEST CAUTION IN TRANSLATING RESULTS OBTAINED IN ANIMALS TO MAN.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在急性铊中毒的情况下，发现人类大脑中神经元密集的区域比其他区域积累了更多的铊，并且灰质中的铊含量高于非神经组织。/可溶性铊化合物/

In acute thallium poisoning, human brain areas densely populated with neurons were found to accumulate thallium more than other areas, and the gray matter contained higher thallium levels than nonneural tissues. /Soluble thallium cmpd/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为产物：
  描述：

  thallium(1+);sulfate 、 硫酸 生成 Bis(2,2-dioxo-1,3,2,4-dioxathiathalletan-4-yl) sulfate
  参考文献：
  名称：

  AIDZAVA, TAKAO

  摘要：

  DOI：

文献信息

• AIDZAVA, TAKAO
  作者：AIDZAVA, TAKAO

  DOI：——

  日期：——