Phosphorsaeure-dimethylester-<(2-pyridyl)-amid> | 90008-29-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphorsaeure-dimethylester-<(2-pyridyl)-amid>
• 英文别名: dimethyl (N-pyridine-2-yl)phosphoramidate；Phosphoramidic acid, 2-pyridinyl-, dimethyl ester；N-dimethoxyphosphorylpyridin-2-amine
• CAS: 90008-29-0
• 化学式: C₇H₁₁N₂O₃P
• 分子量: 202.15
• InChiKey: DAPLIFSHESCAEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氯磷酸二甲酯 、 2-氨基吡啶 生成 Phosphorsaeure-dimethylester-<(2-pyridyl)-amid>
  参考文献：
  名称：

  KHAZANCHI R.; ROY N. K., INDIAN J. AGR. SCI., 56,(1986) N 10, 726-731

  摘要：

  DOI：

文献信息

• Phosphoramidates: Features of the formation mechanism and the relationship structure-bioaction
  作者：V. I. Krutikov、A. V. Erkin、V. V. Krutikova

  DOI：10.1134/s1070363212050039

  日期：2012.5

  Mechanism of the synthesis of phosphoramidates by Todd-Atherton reaction is based on the primary interaction of a polyhaloalkane with the highly basic amine to form a 1:1 associate. The subsequent attack by the associate on the hydrophosphoryl compound of "symmetric" structure leads to the formation of the target compounds in high yields. The test of the effect of dialkyl hexamethylene- and dialkyl(pyridin-2-yl)-phosphoramidates in vitro against the strains of a number of the producents of pathogenic bacteria and mycotoxins showed that the high level of biological activity of the target compounds is correlated well with the physicochemical parameters characterizing their structure.
• KHAZANCHI R.; ROY N. K., INDIAN J. AGR. SCI., 56,(1986) N 10, 726-731
  作者：KHAZANCHI R.、 ROY N. K.

  DOI：——

  日期：——