disodium;1H-indol-3-yl phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: disodium;1H-indol-3-yl phosphate
• 化学式: C8H6NNa2O4P
• 分子量: 257.09
• InChiKey: WCSKWBKPKXJWEG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.62
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] INDOLE-CONTAINING COMPOUNDS WITH ANTI-TUBULIN AND VASCULAR TARGETING ACTIVITY<br/>[FR] COMPOSES CONTENANT DE L'INDOLE A ACTIVITE ANTI-TUBULINE ET DE CIBLAGE VASCULAIRE
  申请人：UNIV BAYLOR

  公开号：WO2004099139A1

  公开（公告）日：2004-11-18

  Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin assembly. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

  已发现了取代三甲氧基苯基吲哚配体，这些配体表现出令人印象深刻的细胞毒性，以及抑制微管组装的显著能力。这类化合物以及相关衍生物是治疗人类癌症的优秀临床候选药物。此外，这些配体中的某些作为前药，很可能被证明是肿瘤选择性血管靶向化疗药物，或具有靶向血管活性，从而选择性地预防和/或破坏非恶性增殖的血管系统。
• Indole-containing compounds with anti-tubulin and vascular targeting activity
  申请人：Pinney G. Kevin

  公开号：US20070082872A1

  公开（公告）日：2007-04-12

  Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin assembly. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

  发现了取代三甲氧基苯基吲哚配体，它们表现出令人印象深刻的细胞毒性以及抑制微管蛋白组装的显著能力。这些化合物以及相关衍生物是治疗人类癌症的优秀临床候选药物。此外，这些配体中的某些作为前药可能证明是肿瘤选择性血管靶向化学治疗药物或具有血管靶向活性，从而选择性预防和/或破坏非恶性增殖血管。
• Enzyme assays
  申请人：Sankyo Company Limited

  公开号：EP0476930A1

  公开（公告）日：1992-03-25

  Accurate enzyme assays suitable for use in immunoassay techniques are now possible for enzymes associated with the dimerisation of indoxyl esters to form the corresponding indigo, the assays utilising the production of hydrogen peroxide from this reaction, which is found to be sufficiently consistent that it can be used to accurately calculate enzyme activity down to levels of 1 in 1000 compared to colorimetric techniques for the same enzymes.

  对于与吲哚基酯二聚形成相应的靛蓝有关的酶，现在可以进行适用于免疫测定技术的精确酶测定，这种测定利用了从这一反应中产生的过氧化氢。
• Medium for detecting and differentiating vancomycin-resistant enterococci
  申请人：OXOID LIMITED

  公开号：EP2186906A2

  公开（公告）日：2010-05-19

  A medium for the growth of vancomycin-resistant Enterococci comprising:- (i) a nutrient medium with an energy source effective to support growth and reproduction of vancomycin-resistant Enterococci; (ii) an effective amount of one or more selective agents to inhibit the growth of microorganisms other than vancomycin-resistant Enterococci; (iii) a Krebs cycle intermediate.

  一种用于耐万古霉素肠球菌生长的培养基，包括 (i) 营养培养基，其中含有有效支持耐万古霉素肠球菌生长和繁殖的能量源； (ii) 一种或多种抑制耐万古霉素肠球菌以外的微生物生长的有效量的选择性制剂； (iii) 克雷布斯循环中间体。
• IMMUNOASSAY USING DYE COMPLEXED ENZYME CONJUGATES
  申请人：QUIDEL CORPORATION

  公开号：EP0648334A1

  公开（公告）日：1995-04-19