Phosphoric acid, mono(2-nitrophenyl) ester, disodium salt | 17573-66-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphoric acid, mono(2-nitrophenyl) ester, disodium salt
• 英文别名: disodium;(2-nitrophenyl) phosphate
• CAS: 17573-66-9
• 化学式: C6H4NNa2O6P
• 分子量: 263.05
• InChiKey: AKJBMINTPVKBGZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.19
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] DERIVATIVES OF 2,3-DIPHENYLCHROMENE USEFUL FOR THE TREATMENT OF CANCER<br/>[FR] DÉRIVÉS DE 2,3-DI(PHÉNYLCHROMÈNE) UTILES POUR LE TRAITEMENT DU CANCER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016097073A1

  公开（公告）日：2016-06-23

  Described herein are compounds that are estrogen receptor modulators of Formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了一种具有公式I的雌激素受体调节剂及其立体异构体、互变异构体或药学上可接受的盐，并具有所述取代基和结构特征。还描述了包括所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂的方法，单独或与其他化合物结合，用于治疗与雌激素受体有关的疾病或症状。
• [EN] INDOLE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'INDOLE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：ANGELETTI P IST RICHERCHE BIO

  公开号：WO2006029912A1

  公开（公告）日：2006-03-23

  The present invention relates to indole compounds of the formula (I): wherein R1, R2, R3, R4, A, E and X are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.

  本发明涉及式(I)的吲哚化合物，其中R1、R2、R3、R4、A、E和X如本文所定义，并其药学上可接受的盐，用于预防和治疗丙型肝炎感染。
• Separation-free specific binding assays using anti-inhibitor antibodies
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0685740A2

  公开（公告）日：1995-12-06

  Specific binding ligands can be detected with an assay which utilizes an immobilized receptor for the ligand, a reporter enzyme, an inhibitor antibody and an anti-inhibitor antibody. Both antibodies are specific for the reporter enzyme. The inhibitor antibody effectively shuts down the activity of the reporter enzyme when it is complexed thereto. The anti-inhibitor antibody binds to the reporter enzyme, does not affect the enzymatic activity, but prevents the binding of the inhibitor antibody. This assay provides a direct correlation of the target specific binding ligand to the signal generated without the use of separation or wash steps.

  特异性结合配体可通过一种检测方法进行检测，该方法利用了配体的固定受体、报告酶、抑制剂抗体和抗抑制剂抗体。两种抗体都对报告酶具有特异性。当抑制剂抗体与报告酶复合物结合时，它能有效地抑制报告酶的活性。抗抑制剂抗体与报告酶结合，不会影响酶的活性，但会阻止抑制剂抗体的结合。这种检测方法提供了目标特异性结合配体与所产生信号的直接相关性，而无需使用分离或洗涤步骤。
• Production of biologically active proteins
  申请人：ERA Biotech, S.A.

  公开号：EP2351834A2

  公开（公告）日：2011-08-03

  A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide fused to a protein sequence that mediates the induction of RPBLA formation is expressed and accumulated in host cells after transformation with an appropriate vector. The eukaryotic host cell does not produce protein bodies in the absence of the fusion protein. Methods for preparing and using the RPBLAs and the fusion protein are also disclosed, as are nucleic acid molecules that encode the fusion proteins.

  本发明公开了一种在宿主真核细胞和生物体内以重组蛋白体样装配（RPBLA）形式表达的融合蛋白。更具体地说，在用适当的载体转化后，一种与介导 RPBLA 形成的蛋白质序列融合的生物活性多肽在宿主细胞中表达和积累。真核宿主细胞在没有融合蛋白的情况下不会产生蛋白体。此外，还公开了制备和使用 RPBLA 和融合蛋白的方法，以及编码融合蛋白的核酸分子。
• Contructs for enhancing immune responses
  申请人：THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

  公开号：US10328146B2

  公开（公告）日：2019-06-25

  Chimeric protein constructs including a herpesvirus glycoprotein D (gD) and a heterologous polypeptide that interact with herpes virus entry mediator (HVEM) and enhance and enhance an immune response against the heterologous polypeptide and methods for their use are provided.

  本研究提供了包括疱疹病毒糖蛋白 D（gD）和异源多肽的嵌合蛋白构建体，它们能与疱疹病毒进入介质（HVEM）相互作用，并能增强和提高针对异源多肽的免疫反应，还提供了使用嵌合蛋白构建体的方法。