P-Nitrophenylphosphatedi(2-amino-2-ethyl-1,3-propanediol)salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: P-Nitrophenylphosphatedi(2-amino-2-ethyl-1,3-propanediol)salt
• 英文别名: [1-hydroxy-2-(hydroxymethyl)butan-2-yl]azanium;(4-nitrophenyl) phosphate
• 化学式: C16H32N3O10P
• 分子量: 457.41
• InChiKey: YVXXRFJXBIWXFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.78
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  246
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Integral multilayer analytical element for use in the measurement of alkaline phosphatase acitivity
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0182179A1

  公开（公告）日：1986-05-28

  An integral multilayer analytical element for use in the measurement of alkaline phosphatase activity, which comprises a porous spreading layer of woven fabric or knitted fabric containing an alkaline phosphatase-sensitive self-developing substrate, a buffer layer containing one or more compounds functioning as a phosphoric acid acceptor and a buffering agent and a support layer in a laminated form.

  一种用于测量碱性磷酸酶活性的整体式多层分析元件，它包括多孔的机织物或针织物铺展层，其中含有对碱性磷酸酶敏感的自显影基质；缓冲层，其中含有一种或多种用作磷酸受体和缓冲剂的化合物；以及层压形式的支撑层。
• METHODS AND COMPOSITIONS FOR INCREASING ALPHA-L-IDURONIDASE ACTIVITY IN THE CNS
  申请人：Armagen Technologies, Inc.

  公开号：EP2997976A1

  公开（公告）日：2016-03-23

  Provided herein are methods and compositions for treating a subject suffering from a deficiency in α-L-Iduronidase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an α-L-Iduronidase. A therapeutically effective systemic dose is based on the specific CNS uptake characteristics of human insulin receptor antibody-α-L-Iduronidase fusion antibodies as described herein.

  本文提供了治疗中枢神经系统中α-L-双糖醛酸酶缺乏症的方法和组合物。这些方法包括全身给药双功能融合抗体，该抗体包含人胰岛素受体抗体和α-L-杜隆糖苷酶。治疗有效的全身给药剂量基于本文所述的人胰岛素受体抗体-α-L-伊多隆酶融合抗体的特定中枢神经系统吸收特性。
• METHODS AND COMPOSITIONS FOR INCREASING ENZYME ACTIVITY IN THE CNS
  申请人：Armagen, Inc.

  公开号：EP3730516A1

  公开（公告）日：2020-10-28

  Provided herein are methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). The bifunctional fusion antibodies provided herein comprise an antibody to an endogenous blood brain barrier (BBB) receptor and an enzyme deficient in mucopolysaccharidosis III (MPS-III). The fusion antibodies provided herein comprise N-sulfoglucosamine sulfohydrolase (SGSH), alpha-N-acetylgulcosaminidase (NAGLU), heparin-alpha-glucosaminide N-acetyltransferase (HGSNAT), or N-acetylglucosamine-6-sulfatase (GNS). The methods of treating an enzyme deficiency in the CNS comprise systemic administration of a fusion antibody provided herein.

  本文提供了治疗中枢神经系统（CNS）酶缺乏症患者的方法和组合物。本文提供的双功能融合抗体包括内源性血脑屏障（BBB）受体抗体和粘多糖病 III（MPS-III）中缺乏的酶。本文提供的融合抗体包括 N-磺葡糖胺磺酰水解酶（SGSH）、α-N-乙酰谷氨酰胺酶（NAGLU）、肝素-α-葡糖胺 N-乙酰转移酶（HGSNAT）或 N-乙酰葡糖胺-6-硫酸酯酶（GNS）。治疗中枢神经系统酶缺乏症的方法包括全身给药本文提供的融合抗体。
• Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
  申请人：ARMAGEN, INC.

  公开号：US10011651B2

  公开（公告）日：2018-07-03

  Provided herein are methods and compositions for treating a subject suffering from a deficiency in iduronate 2-sulfatase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody that crosses the blood brain barrier (BBB) and an iduronate 2-sulfatase.

  本文提供了用于治疗中枢神经系统iduronate 2-硫酸酯酶缺乏症患者的方法和组合物。 这些方法包括全身给药双功能融合抗体，该抗体由可穿过血脑屏障（BBB）的抗体和仲丁酸 2-硫酸酯酶组成。
• Human immunodeficiency virus type 1 (HIV-1) N-terminal deleted GP120 immunogens
  申请人：Kim Jerome

  公开号：US10040826B2

  公开（公告）日：2018-08-07

  The present invention relates, in general, to human immunodeficiency virus (HIV), and in particular to a vaccine for HIV-1 and to methods of making and using same.

  本发明总体上涉及人类免疫缺陷病毒（HIV），特别是涉及 HIV-1 疫苗及其制造和使用方法。