申请人:Bracco International B.V.
公开号:US20040208826A1
公开(公告)日:2004-10-21
Gas or air filled microbubble and microballoon suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. The microbubble suspensions contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The microbubble suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. The microballoons have a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick polymer membrane. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles and gas-filled microballoons used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
水相中的气体或空气填充微泡和微球悬浮液可用作超声波造影术中的成像造影剂。微气泡悬浮液含有层状表面活性剂和亲水性稳定剂。层状表面活性剂可以是脂质体形式。在与水相混合之前或之后,将层状表面活性剂暴露于空气或气体中,可获得微气泡悬浮液。微球的平均尺寸在 0.5 到 1000 微米之间,由 50 到 500 纳米厚的聚合物膜包围。作为填充物,气体在水中的溶解度除以分子量的平方根不超过 0.003。