[(2R,3R,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-1-ium-2-yl]methyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [(2R,3R,4R,5S)-3,4-dihydroxy-5-methylpyrrolidin-1-ium-2-yl]methyl hydrogen phosphate
• 化学式: C6H14NO6P
• 分子量: 227.15
• InChiKey: DBIZEHSUEURUMP-SLPGGIOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Facile approach towards phosphorylated azasugars as potential glycosyl phosphate mimics
  作者：Matthias Schuster、Siegfried Blechert

  DOI：10.1016/s0957-4166(99)00322-5

  日期：1999.8

  A sequence of two chemoselective reductions enables the stereoselective synthesis of phosphorylated azasugars starting from products of dihydroxyacetonephosphate-dependent aldolases. (C) 1999 Elsevier Science Ltd. All rights reserved.
• Inhibition of fucosyltransferase V by a GDP–Azasugar
  作者：Matthias Schuster、Siegfried Blechert

  DOI：10.1016/s0960-894x(01)00282-7

  日期：2001.7

  A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy. (C) 2001 Elsevier Science Ltd. All rights reserved.