Thallium selenite | 12039-52-0

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属氧阴离子化合物
• 英文名称: Thallium selenite
• 英文别名: thallium(1+);selenite
• CAS: 12039-52-0；15123-92-9
• 化学式: O3Se.2Tl
• 分子量: 535.74
• InChiKey: MPMWDEQGDVBQOZ-UHFFFAOYSA-L

物化性质

• 物理描述：
  Selenious acid, dithallium(1+) salt is a solid.
• 颜色/状态：
  Dark gray plates with a metallic luster
• 熔点：
  340 °C
• 溶解度：
  Insoluble in water and acids.
• 分解：
  When heated to decomp ... emits toxic fumes of /thallium and selenium/

计算性质

• 辛醇/水分配系数(LogP)：
  -3.64
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

毒理性

• 致癌性证据

分类：D；无法归类为人类致癌性。分类依据：基于动物和人类致癌性数据的缺乏。人类致癌性数据：不足。动物致癌性数据：无。

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on the lack of carcinogenicity data in animals and humans. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: None.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

以下医疗程序应提供给每个可能接触到潜在有害水平的铊及其化合物的员工：初次医疗检查：进行全面的历史和体格检查：目的是为了检测可能使暴露员工处于增加风险现状的现有条件，并为未来的健康监测建立基准。应强调对眼睛、神经系统、肺、肝、肾、胃肠道的检查和体毛。尿液分析：由于在接触铊的人中已经观察到肾脏损伤，因此应获得尿液分析，至少包括比重、白蛋白、葡萄糖和对离心沉淀物的显微镜检查。定期医疗检查：这些医疗检查应每年重复进行。铊及其化合物

The following medical procedures should be made available to each employee who is exposed to ... thallium /and thallium/ compounds at potentially hazardous levels: Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Examination of the eyes, nervous system, lung, liver, kidneys, gastrointestinal tract, and body hair should be stressed. Urinalysis: Since kidney damage has been observed in humans exposed to thallium, a urinalysis should be obtained to include at a minimum specific gravity, albumin, glucose, and a microscopic /examination/ on centrifuged sediment. Periodic Medical Examination: These medical examinations should be repeated on an annual basis. /Thallium and thallium compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

以下医疗程序应提供给每个可能接触到潜在有害水平的硒及其无机化合物的员工：1. 初始医疗检查：完整的病史和体格检查。目的是检测可能使暴露员工处于增加风险中的现有状况，并为未来的健康监测建立基线。有哮喘、过敏或已知对硒过敏史的人，或有其他慢性呼吸道疾病、胃肠功能紊乱、肝脏或肾脏疾病或复发性皮炎史的人，暴露于硒时风险可能会增加。应强调检查眼睛、呼吸系统、肝脏、肾脏和血液。应检查皮肤，以寻找慢性疾病的证据。特别关注育龄妇女，因为硒可能具有致畸性，这可能会使这些妇女处于高风险组别。尿液分析：为了验证尿液中硒的水平，需要肾脏功能正常。应进行尿液分析，至少包括比重、白蛋白、葡萄糖和对离心沉淀物的显微镜检查。肝功能测试：硒在动物中可导致肝损伤和肿瘤。应通过使用医学上可接受的生物化学测试组合来获得肝功能概况。上述医疗检查应每年重复一次。/硒及其无机化合物/

The following medical procedures should be made available to each employee who is exposed to selenium and its inorganic compounds at potentially hazardous levels: 1. Initial Medical Examination: A complete history and physical examination: The purpose is to detect existing conditions that might place the exposed employee at increased risk, and to establish a baseline for future health monitoring. Persons with a history of asthma, allergies, or known sensitization to selenium, or with a history of other chronic respiratory disease, gastrointestinal disturbances, disorders of liver or kidneys or recurrent dermatitis would be expected to be at increased risk from exposure. Examination of the eyes, respiratory system, liver, kidneys, and blood should be stressed. The skin should be examined for evidence of chronic disorders. Special consideration should be given to women of childbearing age since the possibility that selenium may be teratogenic might place these women in a high risk group. Urinalysis: Proper function of the kidneys is necessary to validate levels of selenium in the urine. A urinalysis should be obtained to include at a minimum specific gravity, albumin, glucose, and a microscopic on centrifuged sediment. Liver function tests: Selenium causes liver damage and tumors in animals. A profile of liver function should be obtained by using a medically acceptable array of biochemical tests. The aforementioned medical examinations should be repeated on an annual basis. /Selenium and its inorganic compounds/

来源:Hazardous Substances Data Bank (HSDB)