三(2,5-二甲苯基)磷酸酯 | 19074-59-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 三(2,5-二甲苯基)磷酸酯
• 英文名称: Tris-<2,5-dimethyl-phenyl>-phosphat
• 英文别名: phosphoric acid tris-(2,5-dimethyl-phenyl ester)；Phosphorsaeure-tris-(2,5-dimethyl-phenylester)；Tris-(2.5-dimethyl-phenyl)-phosphat；Tri-[2.5]xylyl-phosphat；2,5-dimethyl-phenol, phosphate (3:1)；Phosphorsaeure-tri-[2.5]xylylester；phosphoric acid 2,5-xylyl ester；tris(2,5-xylyl) phosphate；tris(2,5-dimethylphenyl) phosphate
• CAS: 19074-59-0
• 化学式: C₂₄H₂₇O₄P
• 分子量: 410.45
• InChiKey: MDHAARLWBHZGIP-UHFFFAOYSA-N

物化性质

• 熔点：
  79.8°C
• 沸点：
  243.75°C (estimate)
• 密度：
  1.1970
• 颜色/状态：
  Crystals (from crystallization with dilute alcohol)
• 溶解度：
  Sol in ether, benzene; slightly soluble in ethanol

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要进行治疗……。监测休克，如有必要进行治疗……。预见并治疗癫痫发作……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽插管以控制气道。使用带有气囊面罩的装置进行正压通气技术可能有益。监测心率和必要时治疗心律失常。 ... 开始静脉输液，使用5%葡萄糖盐水/生理盐水： "保持开放"，最低流速/。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。使用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。 /毒药A和B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2919900090

反应信息

• 作为产物：
  描述：

  2,5-二甲基苯酚 在 三氯氧磷 作用下， 生成 三(2,5-二甲苯基)磷酸酯
  参考文献：
  名称：

  Breusch; Keskin, Istanbul Universitesi Fen Fakultesi Mecmuasi, 1942, vol. 7, p. 182,187

  摘要：

  DOI：

文献信息

• AROMATIC PHOSPHATE ESTERS AS AGROCHEMICAL FORMULATION COMPONENT
  申请人：Syngenta Limited

  公开号：EP2790503A1

  公开（公告）日：2014-10-22
• AROMATIC PHOSPHATE ESTERS AS AGROCHEMICAL FORMULATION COMPONENTS
  申请人：Syngenta Limited

  公开号：EP2790503B1

  公开（公告）日：2017-07-19
• [EN] AROMATIC PHOSPHATE ESTERS AS AGROCHEMICAL FORMULATION COMPONENT<br/>[FR] ESTERS DE PHOSPHATE AROMATIQUES EN TANT QUE COMPOSANT DE FORMULATION AGROCHIMIQUE
  申请人：SYNGENTA LTD

  公开号：WO2013087396A1

  公开（公告）日：2013-06-20

  This invention relates to the use of aromatic phosphate esters of formula (la), wherein X, Y, n and R4 are as defined within the description, as adjuvants in compositions, particularly for agrochemical use, as well to compositions comprising such an aromatic phosphate ester, in combination with at least one agrochemical and optionally at least one surfactant. The invention further extends to methods of making and using such compositions.
• Breusch; Keskin, Istanbul Universitesi Fen Fakultesi Mecmuasi, 1942, vol. <A> 7, p. 182,187
  作者：Breusch、Keskin

  DOI：——

  日期：——