九节碱 | 7633-29-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吐根碱生物碱
• 中文名称: 九节碱
• 中文别名: 环戊甲酰胺,2,3-二羟基-4-(羟甲基)-,(1-alpha-,2-ba-,3-ba-,4-alpha-)-(9CI)
• 英文名称: psychotrine
• 英文别名: Psychotrin；1-[[(2R,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-3,4-dihydroisoquinolin-6-ol
• CAS: 7633-29-6
• 化学式: C₂₈H₃₆N₂O₄
• 分子量: 464.605
• InChiKey: NCALAYAMQHIWMN-REIDKSKDSA-N

物化性质

• 沸点：
  613.4±55.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)
• 熔点：
  122 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  63.5
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险等级：
  6.1(b)

文献信息

• Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use
  申请人：Babul Najib

  公开号：US20120065221A1

  公开（公告）日：2012-03-15

  The present invention is directed to oral, therapeutically effective extended release pharmaceutical compositions of 3-hydroxy-N-methylmorphinan, including delayed onset, extended release dosage forms and the use thereof.

  本发明涉及口服、治疗有效的3-羟基-N-甲基吗啡酮的延迟作用、延长释放药物组成物，包括延迟起效、延长释放剂型及其使用。
• Oral Pharmaceutical Compositions of Buprenorphine and Method of Use
  申请人：BABUL Najib

  公开号：US20120178771A1

  公开（公告）日：2012-07-12

  The present invention is directed to oral, therapeutically effective pharmaceutical compositions of buprenorphine and it pharmaceutically acceptable salts and the use thereof, including delayed onset and controlled release dosage forms. The present invention is also directed delayed onset, rapid release dosage forms and delayed onset, extended release dosage forms of oral buprenorphine which provide robust efficacy and reduced potential for abuse and misuse.

  本发明涉及布洛芬静脉注射剂的制备方法，其特点在于提供了一种口服的、治疗有效的布洛芬药物组合物，包括布洛芬及其药学上可接受的盐，并且包括延迟发挥和控制释放的剂型。本发明还涉及口服布洛芬的延迟发挥、快速释放和延迟发挥、持续释放剂型，这些剂型提供了强大的疗效，并减少了滥用和误用的潜在风险。
• Detergent compositions containing compatible organic emetic agent
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0178029A2

  公开（公告）日：1986-04-16

  Detergent compositions, preferably liquid compositions which are substantially free of polyphosphate builders, containing surface-active agents, and low level of a detergent compatible organic emetic agent are disclosed.

  本发明公开了洗涤剂组合物，最好是基本上不含聚磷酸盐制造剂的液体组合物，其中含有表面活性剂和低浓度的洗涤剂兼容有机催吐剂。
• Methods and compositions for deterring abuse of opioid containing dosage forms
  申请人：ACURA PHARMACEUTICALS, INC.

  公开号：EP2402004A2

  公开（公告）日：2012-01-04

  This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.

  本发明涉及一种阿片类镇痛药的抑制滥用剂型，其中镇痛有效量的阿片类镇痛药与聚合物结合形成基质。
• Tamper resistant pharmaceutical formulations
  申请人：Purdue Pharma L.P.

  公开号：US10195152B2

  公开（公告）日：2019-02-05

  Disclosed in certain embodiments is a solid oral dosage form comprising a plurality of particles, each particle comprising (i) a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material. The dosage form can also include an alcohol resistant material.

  在某些实施例中，公开了一种固体口服剂型，它包括多个颗粒，每个颗粒包括(i) 由易滥用的活性剂和内部粘附促进剂组成的核心，其中核心(i) 分散在由控释材料组成的基质中，或(ii) 涂有控释材料。剂型还可包括耐酒精材料。