1,5-diazabicyclo [5.4.0] undecene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮卓类
• 英文名称: 1,5-diazabicyclo [5.4.0] undecene
• 英文别名: 1,5-diazabicyclo [5.4.0]-undecene；1,5-diazabicyclo[5.4.0] undecene；1,5-diazabicyclo[5,4,0]undecene；1,5-diazabicyclo[5.4.0]undecene；1,2,3,7,8,9,10,10a-octahydropyrido[1,2-a][1,4]diazepine
• 化学式: C₉H₁₆N₂
• 分子量: 152.239
• InChiKey: MYBOTUJPOSBJSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,5-diazabicyclo [5.4.0] undecene 、 2-(N-isopropyl-2-hydroxyhexylsulfonylamino)-5-trifluoromethylphenyl methoxymethyl ether 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 、 氩 为溶剂， 生成 2-(N-isopropyl-1-hexenylsulfonylamino)-5-trifluoromethylphenyl methoxymethyl ether
  参考文献：
  名称：

  Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient

  摘要：

  化合物的结构式（I）的磺胺基或碳酰胺衍生物及其作为活性成分的药物组合物：（其中A环，B环是碳环，杂环；Z1是—COR1，—CH═CH—COR1等；Z2是H，烷基等；Z3是单键，烷基；Z4是SO2，CO；Z5是烷基，苯基，杂环等；R2是CONR8，O，S，NZ6，Z7-烷基，烷基等；R3是H，烷基，卤素，CF3等；R4是H，（取代）烷基等；n，t为1-4）。结构式（I）的化合物可以结合到PGE2的受体上，并显示对其作用的拮抗活性或激动活性。因此，它们被认为在抑制子宫收缩、镇痛剂、止泻药、催眠剂、增加膀胱容量的药物、子宫收缩药物、通便剂、抑制胃酸分泌、降压或利尿剂方面是有用的。

  公开号：

  US06448290B1
• 作为试剂：
  描述：

  1aα,2,3,4α-tetrabromo-1a,2,3,4,-tetrahydro-1H-cyclobutanaphthalene 在 1,5-diazabicyclo [5.4.0] undecene 作用下， 以74%的产率得到2,4-dibromo-1H-cyclobutanaphthalene
  参考文献：
  名称：

  1-环丁[ ]萘的芳族取代和加成反应

  摘要：

  1- Cyclobuta [ ]萘在其C-4和C-5位置进行亲电取代；1-环丁[ ]萘的光解溴化反应生成1,2,3,4四溴-1,2,3,4-四氢-1-环丁[ ]萘。

  DOI：

  10.1016/s0040-4039(00)98421-1

文献信息

• IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE
  申请人：Fresenius Kabi Oncolgy Limited

  公开号：US20150183789A1

  公开（公告）日：2015-07-02

  An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.

  一种改进的用于制备辛伐替泼的工艺，更安全。该发明还涉及用于制备辛伐替泼的新型中间体及其工艺。本发明还涉及一种基本纯度的辛伐替泼和一种高产率获得其的工艺。
• Method of preparing 2-phenyl benezothriazoles
  申请人：Chemipro Kasei Kaisha, Ltd.

  公开号：US05104992A1

  公开（公告）日：1992-04-14

  A method of preparing 2-phenylbenzotriazoles expressed by Formula I: ##STR1## (wherein R.sub.1 denotes a hydrogen or chlorine atom, a lower alkyl group having 1 to 4 carbon atoms, a lower alkoxyl group having 1 to 4 carbon atoms, a carboxyl group or a sulfonic acid group; R.sub.2 denotes a hydrogen or chlorine atom, a lower alkyl group having 1 to 4 carbon atoms or a lower alkoxyl group having 1 to 4 carbon atoms; R.sub.3 denotes a hydrogen or chlorine atom, an alkyl group having 1 to 12 carbon atoms, a lower alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted by an alkyl group having 1 to 8 carbon atoms, a phenoxy group or a phenylalkyl group with an alkyl part having 1 to 4 carbon atoms; R.sub.4 denotes a hydrogen or chlorine atom, a hydroxyl group or an alkoxyl group having 1 to 4 carbon atoms; and R.sub.5 denotes a hydrogen atom, an alkyl group having 1 to 12 carbon atoms or a phenylalkyl group with an alkyl part having 1 to 4 carbon atoms) comprises reducing with hydrogen 2-phenylbenzotriazole-N-oxides expressed by Formula II: ##STR2## (wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each denotes the same as in Formula I).

  一种制备由式I表示的2-苯基苯并三氮唑的方法：##STR1##（其中R.sub.1表示氢原子或氯原子，具有1至4个碳原子的低碳链基，具有1至4个碳原子的低碳氧基，羧基或磺酸基；R.sub.2表示氢原子或氯原子，具有1至4个碳原子的低碳链基或具有1至4个碳原子的低碳氧基；R.sub.3表示氢原子或氯原子，具有1至12个碳原子的烷基，具有1至4个碳原子的低碳氧基，苯基，被具有1至8个碳原子的烷基取代的苯基，苯氧基或具有1至4个碳原子的烷基部分的苯基烷基；R.sub.4表示氢原子或氯原子，羟基或具有1至4个碳原子的烷氧基；R.sub.5表示氢原子，具有1至12个碳原子的烷基或具有1至4个碳原子的烷基部分的苯基烷基）包括用氢还原由式II表示的2-苯基苯并三氮唑-N-氧化物：##STR2##（其中R.sub.1、R.sub.2、R.sub.3、R.sub.4和R.sub.5分别与式I中相同）。
• [EN] IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE<br/>[FR] PROCÉDÉ PERFECTIONNÉ POUR LA PRÉPARATION DE PRALATREXATE
  申请人：FRESENIUS KABI ONCOLOGY LTD

  公开号：WO2014016740A2

  公开（公告）日：2014-01-30

  An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.

  本发明提供了一种制备Pralatrexate的改进工艺，该工艺更加安全。本发明还涉及用于制备Pralatrexate的新型中间体及其工艺。本发明还涉及一种高产得到Pralatrexate的工艺和高度纯净的Pralatrexate。
• Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-halogen steroids that can be produced therefrom, their process for production and use as well as pharmaceutical prepartions that contain these compounds, as well as 7-substituted estra-1,3,5(10)-trienses that can be produced therefrom
  申请人：Zorn Ludwig

  公开号：US20050090477A1

  公开（公告）日：2005-04-28

  A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R 7 , R 10 , R 11 , R 13 , R 17 and R 17′ as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.

  本文介绍了一种新的合成方法，用于制造通式为8、10和12的化合物的上游产品。在这种合成中，通式为4-B的化合物是通过微生物反应产生的。在权利要求中指出了R7、R10、R11、R13、R17和R17'的含义，以及U-V-W-X-Y-Z的分组。
• Androgenic 7-substituted 11-halogen steroids
  申请人：Bohlmann Rolf

  公开号：US20050075322A1

  公开（公告）日：2005-04-07

  The invention relates to 11β-halogen steroids with general formula (I), whereby R 11 is halogen, X—Y-Z represents a group with one of the two structures CH═C—C or CH 2 —C═C and the other radicals have the meaning that is indicated in the claims, also the production and use of these compounds for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11β-halogen steroids.

  本发明涉及具有通式（I）的11β-卤代类固醇，其中R11是卤素，X—Y-Z表示具有两种结构之一的基团，即CH═C—C或CH2—C═C，其他基团的含义如权利要求中所示，同时还涉及这些化合物的制备和用于制备含有11β-卤代类固醇的药物制剂。