5H-吡咯并[1,2-a][1,4]二氮杂卓 | 38895-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮卓类
• 中文名称: 5H-吡咯并[1,2-a][1,4]二氮杂卓
• 英文名称: 5H-Pyrrolo[1,2-a][1,4]diazepine
• CAS: 38895-71-5
• 化学式: C₈H₈N₂
• 分子量: 132.16
• InChiKey: NBFABZHUOJWSDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  9,10-dihydro-10-(4-nitrobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine 、 乙酸乙酯 在 钯 silica gel 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 5H-吡咯并[1,2-a][1,4]二氮杂卓
  参考文献：
  名称：

  Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

  摘要：

  公式为：##STR1## 其中A、B、D、E、F、Y和Z在规范中有定义的三环二氮杂苯类化合物具有抗利尿激素和催产素拮抗剂活性。

  公开号：

  US05516774A1

文献信息

• AGENTS FOR TREATING PAIN AND USES THEREOF
  申请人：ABBVIE INC.

  公开号：US20140171423A1

  公开（公告）日：2014-06-19

  This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

  这项发明涉及：(a) 化合物及其盐，用于治疗疼痛等症状；(b) 用于制备这些化合物和盐的中间体；(c) 包括这些化合物和盐的组合物；(d) 制备这些中间体、化合物、盐和组合物的方法；(e) 使用这些化合物、盐和组合物的方法；以及(f) 包括这些化合物、盐和组合物的试剂盒。
• [EN] NOVEL SUBSTITUTED IMIDAZOPYRIMIDINES AS GPBAR1 RECEPTOR MODULATORS<br/>[FR] NOUVEAUX IMIDAZOPIRIDINES SUBSTITUES COMME MODULATEURS RECEPTEURS GPBAR1
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2013057650A1

  公开（公告）日：2013-04-25

  The present invention relates to novel substituted imidazo[1,2-a]pyrimidine compounds of formula (I), their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further" relates to the use of the above- mentioned compounds for the preparation of medicament for use as pharmaceuticals. (Formula I).

  本发明涉及新型取代咪唑[1,2-a]嘧啶化合物（式I），其药学上可接受的盐以及其异构体、立体异构体、构象体、互变异构体、多晶形态、水合物和溶剂合物。本发明还涵盖所述化合物的药学上可接受的组合物和制备新型化合物的方法。该发明进一步涉及上述化合物用于制备用作药物的药物的用途。 (式I)。
• Novel Substituted Imidazopyrimidines as Gpbar1 Receptor Modulators
  申请人：Torrent Pharmaceuticals Limited.

  公开号：US20150126530A1

  公开（公告）日：2015-05-07

  The present invention relates to novel substituted imidazo[1,2-a]pyrimidine compounds of formula (I), their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further” relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals. (Formula I).

  本发明涉及一种新型的取代咪唑[1,2-a]嘧啶化合物（I）及其药用盐、其异构体、立体异构体、构象体、互变异构体、多晶型、水合物和溶剂合物。本发明还包括所述化合物的药用组合物和制备新化合物的方法。该发明还涉及上述化合物用于制备药物用作药品的用途。
• [EN] NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES<br/>[FR] NOUVELLES 5,6-DIHYDRO-4H-PYRROLO-[1,2-A][1,4]BENZODIAZÉPINES ET 6H-PYRROLO[1,2-A][1,4]BENZODIAZÉPINES ANTIFONGIQUES SUBSTITUÉES PAR DES DÉRIVÉS BICYCLIQUES DU BENZÈNE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012084804A1

  公开（公告）日：2012-06-28

  The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo- [1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及一种新型抗真菌5,6-二氢-4H-吡咯- [1,2-a][1,4]苯并二氮杂环和6H-吡咯- [1,2-a][1,4]苯并二氮杂环，其被取代为公式（I）中的双环苯衍生物，其中R1，R2，R3，R4，R5，R6和R7具有权利要求中定义的含义。根据本发明的化合物主要对抗皮肤癣和系统性真菌感染具有活性。该发明还涉及制备这种新型化合物的工艺、含有该化合物作为活性成分的药物组合物以及将该化合物用作药物的用途。
• [EN] NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO- DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES<br/>[FR] NOUVELLES 5,6-DIHYDRO-4H-PYRROLO[1,2-A][1,4]BENZODIAZÉPINES ET 6H-PYRROLO[1,2-A][1,4]BENZODIAZÉPINES SUBSTITUÉES PAR DES DÉRIVÉS HÉTÉROCYCLIQUES ANTIFONGIQUES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2012150305A1

  公开（公告）日：2012-11-08

  The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo- [1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I) wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及一种新型抗真菌5,6-二氢-4H-吡咯并[1,2-a][1,4]苯二氮杂环和6H-吡咯并[1,2-a][1,4]苯二氮杂环，其被杂环衍生物取代的化合物，其化学结构如下所示（I）式，其中R1、R2、R3、R4和Het在权利要求中定义了含义。根据本发明的化合物主要对皮肤真菌和全身真菌感染具有活性。本发明还涉及制备这种新型化合物的方法，包括将这些化合物作为活性成分的药物组合物以及将这些化合物用作药物的用途。