9-[(4-fluorophenyl)sulfonyl]-1,6-dimethyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Pyrroloazepines
• 英文名称: 9-[(4-fluorophenyl)sulfonyl]-1,6-dimethyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole
• 英文别名: 9-(4-fluorophenyl)sulfonyl-1,6-dimethyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]indole
• 化学式: C₂₀H₂₁FN₂O₂S
• 分子量: 372.463
• InChiKey: LWVQHOMZILLOPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
  申请人：——

  公开号：US20040054170A1

  公开（公告）日：2004-03-18

  The present invention discloses radioligands of 9-arylsulfone of the formula (X) 1 or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

  本发明公开了9-芳基砜的放射配体，其化学式为(X)1或其药用可接受的盐或对映体，可用于诊断抑郁症、肥胖症和其他中枢神经系统疾病。
• [EN] 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-B]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION<br/>[FR] 1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-B]INDOLES PORTANT DES ARYLSULFONES EN POSITION 9
  申请人：UPJOHN CO

  公开号：WO2004096809A1

  公开（公告）日：2004-11-11

  The present invention discloses radioligands of 9-arylsulfone of the formula (I), or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

  本发明揭示了9-芳基砜的放射配体的化学式(I)，或其药用可接受的盐或对映体，它们在诊断抑郁症、肥胖和其他中枢神经系统疾病方面很有用。
• 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
  申请人：Pharmacia & Upjohn Company

  公开号：US20020111483A1

  公开（公告）日：2002-08-15

  The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compound of EXAMPLE 13 1 which are useful in treating depression, obesity and other CNS disorders.

  本发明涉及替代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（X）和未取代的9-芳基砜-1,2,3,4,5,6-环己氮并[4,5-b]吲哚（XI），例如示例131中的化合物，可用于治疗抑郁症、肥胖症和其他中枢神经系统疾病。
• 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position
  申请人：——

  公开号：US20040248880A1

  公开（公告）日：2004-12-09

  The present invention discloses radioligands of 9-arylsulfone of the formula (X) 1 or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

  本发明揭示了公式（X）1的9-芳基磺酰基放射性配体，或其药学上可接受的盐或对映体，它们在诊断抑郁症、肥胖症和其他中枢神经系统疾病方面是有用的。
• 1,2,3,4,5,6-HEXAHYDROAZEPINO 4,5-b]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1196417A1

  公开（公告）日：2002-04-17