D-Fructose-1-phosphat

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: D-Fructose-1-phosphat
• 英文别名: beta-D-fructopyranose 1-phosphate；[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: HXRNACQBNUPKDX-ARQDHWQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Mannose-6-phosphate-binding antibodies and their uses
  申请人：Universitätsklinikum Hamburg-Eppendorf

  公开号：EP2151687A1

  公开（公告）日：2010-02-10

  The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.

  本发明涉及一种特异性结合 6-磷酸甘露糖的分离抗体或其抗原结合片段，以及制备这种抗体或其抗原结合片段的方法。本发明还涉及编码这种抗体或抗体片段的核酸分子、包含这种核酸分子的表达载体和包含这种核酸分子或表达载体的宿主细胞。本发明还涉及一种从样品中纯化或浓缩包含至少一个 6-磷酸甘露糖残基的目标分子的方法。在另一个方面，本发明涉及一种诊断疾病的方法，该疾病的特征是具有 6-磷酸甘露糖残基的分子没有修饰或修饰减少。最后，本发明涉及本发明抗体或抗体片段在医学中的用途，特别是用于诊断以 6-磷酸甘露糖残基分子修饰缺失或修饰减少为特征的疾病。
• MANNOSE-6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES
  申请人：Universitätsklinikum Hamburg-Eppendorf

  公开号：EP2329267B1

  公开（公告）日：2013-07-17
• ENZYMATIC TRANSPHOSPHORYLATION OF SUGAR SUBSTRATES
  申请人：BASF SE

  公开号：EP3194606A1

  公开（公告）日：2017-07-26
• MANNOSE 6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES
  申请人：Braulke Thomas

  公开号：US20110201023A1

  公开（公告）日：2011-08-18

  The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.
• [EN] MANNOSE-6-PHOSPHATE-BINDING ANTIBODIES AND THEIR USES<br/>[FR] ANTICORPS DE LIAISON AU MANNOSE-6-PHOSPHATE ET LEURS UTILISATIONS
  申请人：UNIVERSITAETSKLINIKUM HAMBURG

  公开号：WO2010015683A1

  公开（公告）日：2010-02-11

  The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues. Finally, the invention relates to the use of an antibody or antibody fragment of the invention for use in medicine, in particular for the diagnosis of a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.