2-[[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]amino]ethyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2-[[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]amino]ethyl dihydrogen phosphate
• 化学式: C₂₀H₃₆NO₅P
• 分子量: 401.5
• InChiKey: PAMTZZSJCFTYKL-PDBXOOCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Novel cytotoxic compounds and their Use
  申请人：——

  公开号：US20030171338A1

  公开（公告）日：2003-09-11

  Novel amides of polyunsaturated fatty acids with cysteamine-S-phosphate have been synthesized. Combinations of the all-trans-retinoic acid and/or amides of the 13-cis-retinoic acid with O-phospho-L-tyrosine, and N-docosahex-aenoyl-cysteamine-S-phosphate, N-eicosapentaenoyl-cysteamine-S-phosphate, N-arachidonoyl-cysteamine-S-phosphate, N-&agr;-linolenoyl-cysteamine-S-phosphate, and N-&ggr;-linolenoyl-cysteamine-S-phosphate and their analogues N-docosahex-aenoyl-O-phospho-2-aminoethanol, N-eicosapentaenoyl-O-phospho-2-aminoethanol, N-arachidonoyl-O-phospho-2-aminoethanol, N-&agr;-linolenoyl-O-phospho-2-aminoethanol, N-&ggr;-linolenoyl-O-phospho-2-aminoethanol in different compositions exhibit a marked cell-growth inhibiting effect and display anti-tumour activity.

  已经合成了多不饱和脂肪酸的新型酰胺，其中含有半胱氨酸-S-磷酸盐。全反式视黄酸和/或13-顺-视黄酸酰胺与O-磷酸-L-酪氨酸、N-二十二碳六烯酰半胱氨酸-S-磷酸盐、N-二十碳五烯酰半胱氨酸-S-磷酸盐、N-花生四烯酰半胱氨酸-S-磷酸盐、N-α-亚麻酸半胱氨酸-S-磷酸盐和N-γ-亚麻酸半胱氨酸-S-磷酸盐及其类似物N-二十二碳六烯酰-O-磷酸-2-氨基乙醇、N-二十碳五烯酰-O-磷酸-2-氨基乙醇、N-花生四烯酰-O-磷酸-2-氨基乙醇、N-α-亚麻酸-O-磷酸-2-氨基乙醇、N-γ-亚麻酸-O-磷酸-2-氨基乙醇以不同的组合，表现出明显的抑制细胞生长的效果，并显示出抗肿瘤活性。
• Polyunsaturated fatty acid derivatives and their use
  申请人：——

  公开号：US20010037032A1

  公开（公告）日：2001-11-01

  Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2-aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-L-tyrosine containing phosphate groups. Further, the present invention discloses the synthesis and use of these compounds, in particular their pharmaceutical application.

  本发明公开了新型酰胺，特别是所有-反式-视黄酸或13-顺-视黄酸和花生四烯酸、二十二碳六烯酸、二十碳五烯酸或亚油酸与2-氨基乙醇、α-L-丝氨酸、α-L-苏氨酸、α-L-酪氨酸含磷酸基。此外，本发明还公开了这些化合物的合成和使用，特别是它们在药学上的应用。
• New compounds for the treatment of cancer
  申请人：ARDENIA INVESTMENTS, LTD.

  公开号：US20010018425A1

  公开（公告）日：2001-08-30

  It is shown that the potency of anti-cancer drugs, here exemplified by doxorubicin, can be increased by the use of polyunsaturated fatty acid amides and in particular specific combinations of such compounds, forming complexes with doxorubicin. Further, a modified form of doxorubicin is presented.

  研究表明，使用多不饱和脂肪酸酰胺，特别是这类化合物的特定组合，与多柔比星形成复合物，可以提高抗癌药物（这里以多柔比星为例）的药效。此外，还介绍了一种改良形式的多柔比星。
• POLYUNSATURATED FATTY ACID DERIVATIVES AND THEIR USE
  申请人：Ardenia Investments Ltd.

  公开号：EP1161436A1

  公开（公告）日：2001-12-12
• COMPOUNDS FOR THE TREATMENT OF CANCER
  申请人：Ardenia Investments Ltd.

  公开号：EP1159756A2

  公开（公告）日：2001-12-05