Pentadecan-8-yl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Pentadecan-8-yl dihydrogen phosphate
• 化学式: C₁₅H₃₃O₄P
• 分子量: 308.39
• InChiKey: YWOIMIFPWICXIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
  申请人：Burke, Jr. Terrence R.

  公开号：US10266565B2

  公开（公告）日：2019-04-23

  Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

  提供了一种新型化合物，通过波洛盒结构结合波洛样激酶。在某些实施例中，这些新型化合物是PEG化肽。根据本发明，这些PEG化肽表现出高PBD结合亲和力。在某些实施例中，这些PEG化肽在整个细胞系统中也表现出活性。本发明还提供了一种通过波洛盒结构结合波洛样激酶且具有降低阴离子电荷的化合物。此外，还提供了PEG化肽的设计和/或合成方法以及使用这些方法。本发明提供了这些化合物的使用方法和合成方法。
• Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
  申请人：——

  公开号：US20040235949A1

  公开（公告）日：2004-11-25

  The present invention relates to compounds and pharmaceutical compositions useful for treating pain. The invention also relates to methods of treating or alleviating pain in mammals, comprising administering to a mammal suffering from pain, a pain-alleviating amount of a compound of the general formula (I) or (II).

  本发明涉及用于治疗疼痛的化合物和药物组合物。该发明还涉及治疗或缓解哺乳动物疼痛的方法，包括向患有疼痛的哺乳动物施用一定量的一般式（I）或（II）的化合物。
• Derivatives of branched-chain lipophilic molecules and uses thereof
  申请人：——

  公开号：US20030186897A1

  公开（公告）日：2003-10-02

  The present invention discloses novel phospho-derivatives of branched-chain lipophilic molecules useful for permeabilizing biological barriers and for inhibiting tumor growth. The invention further discloses pharmaceutical compositions comprising said molecules and their uses.

  本发明揭示了新型分支链亲脂分子的磷酸衍生物，可用于渗透生物屏障和抑制肿瘤生长。本发明还揭示了包含该分子的制药组合物及其用途。
• Derivatives of branch-chain lipophilic molecular and uses thereof
  申请人：Kozak Alexander

  公开号：US20070135381A1

  公开（公告）日：2007-06-14

  Novel phospho-derivatives of branched-chain lipophilic molecules useful for permeabilizing biological barriers and for inhibiting tumor growth are disclosed. Pharmaceutical compositions comprising said molecules and their uses are also disclosed.

  本发明公开了新型支链脂溶性分子的磷酸衍生物，其可用于渗透生物屏障并抑制肿瘤生长。同时，还公开了包含该分子的制药组合物及其用途。
• LPA Receptor Agonists and Antagonists
  申请人：Gududuru Veeresh

  公开号：US20120010424A1

  公开（公告）日：2012-01-12

  Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.

  本发明涉及公式（I）所示的化合物，以及包括这些化合物的制药组合物。本发明还涉及使用这些化合物的方法，这些化合物具有作为LPA受体的激动剂或拮抗剂的活性；这些方法包括治疗癌症、产生放射保护和/或减轻放射损伤、增强细胞增殖、治疗伤口、治疗凋亡或保护或恢复细胞、组织或器官的功能、培养细胞、保护器官或组织功能，以及治疗皮肤病症。