2,2-二(溴甲基)-3-氯丙基二[2-氯-1-(氯甲基)乙基]磷酸酯 | 66108-37-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 2,2-二(溴甲基)-3-氯丙基二[2-氯-1-(氯甲基)乙基]磷酸酯
• 英文名称: 2,2-Bis(bromomethyl)-3-chloropropyl bis(2-chloro-1-(chloromethyl)ethyl) phosphate
• 英文别名: [2,2-bis(bromomethyl)-3-chloropropyl] bis(1,3-dichloropropan-2-yl) phosphate
• CAS: 66108-37-0
• 化学式: C₁₁H₁₈Br₂Cl₅O₄P
• 分子量: 582.3
• InChiKey: XPNOZWKYSGBXLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• TSCA 测试提交

双(1,3-二氯-2-丙基)-3-氯-2,2-二溴甲基-1-丙基磷酸(MC984)在大鼠显性致死试验中的效果进行了检测。十只雄性查尔斯河大鼠每天一次连续5天接受了1.1克/千克的测试物质，以玉米油为溶剂，之后与雌鼠交配。在处理后的第一周内进行交配时，观察到孕鼠中死亡植入的比例显著增加（t检验，p < 0.05）。在接受处理后的1到7周内受孕的雌鼠中，有一个或更多，或两个或更多死亡植入的比例以及平均吸收胎数、着床前损失、黄体和每只孕鼠的植入数与对照组相比，差异没有统计学意义。在测试期间没有观察到MC984的显著毒性效应，尽管研究人员在之前的一项研究中观察到在1.6克/千克/天的剂量下的毒性效应（类型和程度未具体说明）。

The effect of bis(1,3-dichloro-2-propyl)-3-chloro-2,2- dibromomethyl -1-propyl phosphate (MC984) was examined in the dominant lethal assay in rats. Ten male Charles River rats received 1.1 g/kg test article in corn oil 1x daily for 5 consecutive days and were then mated. A statistically significant (t-test, p < 0.05) increase in the proportion of dead to total implants was observed in pregnant females when matings occurred 1 week after treatment. The proportion of females with one or more, or two or more dead implantations, and the average number of resorptions, preimplantation losses, corpora lutea, and implantations per pregnant female were not statistically significantly different from controls in females impregnated within 1 to 7 weeks after treatment. Significant toxic effects of MC984 were not observed during the test, although the investigators observed toxic effects (type and degree not specified) in a previous study at 1.6 g/kg/day.

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• FLAME RETARDANT RADIATION CURABLE COMPOSITIONS
  申请人：DSM IP Assets B.V.

  公开号：EP1689800A1

  公开（公告）日：2006-08-16
• [EN] FLAME RETARDANT RADIATION CURABLE COMPOSITIONS<br/>[FR] COMPOSITIONS IGNIFUGES DURCISSABLES PAR EXPOSITION A UN RAYONNEMENT
  申请人：DSM IP ASSETS BV

  公开号：WO2005054330A1

  公开（公告）日：2005-06-16

  The invention relates to a radiation curable composition comprising radiation curable components wherein the composition comprises at least two flame retardants and wherein the flame retardants belong to different classes of compounds, to a process for making three dimensional flame retardant articles and to a three dimensional article, made by rapid prototyping means, that passes the flame retardancy UL-94-VO test.