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氯吡卓醇 | 42863-81-0

中文名称
氯吡卓醇
中文别名
氯吡西泮
英文名称
Lopirazepam
英文别名
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydropyrido[3,2-e][1,4]diazepin-2-one
氯吡卓醇化学式
CAS
42863-81-0
化学式
C14H9Cl2N3O2
mdl
——
分子量
322.15
InChiKey
JEJOFYTVMFVKQA-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.7
  • 重原子数:
    21
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.07
  • 拓扑面积:
    74.6
  • 氢给体数:
    2
  • 氢受体数:
    4

反应信息

  • 作为反应物:
    描述:
    氯吡卓醇 在 Britton Robinson buffer 作用下, 以 甲醇 为溶剂, 反应 3.0h, 以73%的产率得到5-(2-Chlorphenyl)-7-chlor-2,3,4,5-tetrahydro-1H-pyrido[3,2-e]-1,4-diazepin-2-on
    参考文献:
    名称:
    Abu-Khurmah; Oelschlaeger; Engel, Pharmazie, 1997, vol. 52, # 10, p. 775 - 780
    摘要:
    DOI:
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文献信息

  • Conjugated psychotropic drugs and uses thereof
    申请人:——
    公开号:US20040242570A1
    公开(公告)日:2004-12-02
    Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
    本发明揭示了精神药物和有机酸的新型化学结合物,其在治疗精神病和/或增生性疾病和疾病以及作为化学增敏剂中的应用,所述的有机酸被选择用于减少由精神药物引起的副作用和/或发挥抗增殖活性。同时,本发明还揭示了这些化合物的合成方法。
  • Diagnostic/therapeutic agents
    申请人:Klaveness Jo
    公开号:US20050002865A1
    公开(公告)日:2005-01-06
    Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
    可定位的诊断和/或治疗活性剂,例如超声对比剂,包括悬浮在载体液中的报告物,该报告物包含含气体或生成气体的材料,该剂能够与目标形成至少两种结合对。
  • CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AND THEIR USE IN TREATING CNS DISORDERS
    申请人:Nudelman Abraham
    公开号:US20090304584A1
    公开(公告)日:2009-12-10
    Conjugates of a gamma-aminobutyric acid (GABA) compound or a glycine compound and an analgesic drug are disclosed. Further disclosed are pharmaceutical compositions containing these conjugates and uses thereof in the treatment of CNS-associated diseases or disorders, optionally in combination with a psychotropic drug.
    本发明揭示了伽玛-丁酸(GABA)化合物或甘酸化合物和镇痛药物的共轭物。此外,还揭示了包含这些共轭物的制药组合物以及在治疗与中枢神经系统相关的疾病或障碍方面的用途,可选择与精神药物联合使用。
  • NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS
    申请人:STEIN Gideon
    公开号:US20120277310A1
    公开(公告)日:2012-11-01
    A conjugate comprising L-DOPA covalently linked to at least one γ-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.
    本发明揭示了一种共轭物,包括L-DOPA与至少一种γ-丁酸GABA)基团共价连接,以及它的酯和/或加成盐,以及它们在治疗神经退行性疾病或障碍方面的用途。
  • CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF
    申请人:Nudelman Abraham
    公开号:US20120309748A1
    公开(公告)日:2012-12-06
    Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
    本发明揭示了精神药物和有机酸的新型化学结合物,其用途包括治疗精神病和/或增生性疾病,作为化疗增敏剂,并且还揭示了它们的合成方法。所选有机酸被选择为减少精神药物引起的副作用和/或发挥抗增殖活性。
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