(3S)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydropyrido[3,2-e][1,4]diazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶二氮卓类
• 英文名称: (3S)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydropyrido[3,2-e][1,4]diazepin-2-one
• 化学式: C₁₄H₉Cl₂N₃O₂
• 分子量: 322.1
• InChiKey: JEJOFYTVMFVKQA-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Conjugated psychotropic drugs and uses thereof
  申请人：——

  公开号：US20040242570A1

  公开（公告）日：2004-12-02

  Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.

  本发明揭示了精神药物和有机酸的新型化学结合物，其在治疗精神病和/或增生性疾病和疾病以及作为化学增敏剂中的应用，所述的有机酸被选择用于减少由精神药物引起的副作用和/或发挥抗增殖活性。同时，本发明还揭示了这些化合物的合成方法。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AND THEIR USE IN TREATING CNS DISORDERS
  申请人：Nudelman Abraham

  公开号：US20090304584A1

  公开（公告）日：2009-12-10

  Conjugates of a gamma-aminobutyric acid (GABA) compound or a glycine compound and an analgesic drug are disclosed. Further disclosed are pharmaceutical compositions containing these conjugates and uses thereof in the treatment of CNS-associated diseases or disorders, optionally in combination with a psychotropic drug.

  本发明揭示了伽玛-氨基丁酸(GABA)化合物或甘氨酸化合物和镇痛药物的共轭物。此外，还揭示了包含这些共轭物的制药组合物以及在治疗与中枢神经系统相关的疾病或障碍方面的用途，可选择与精神药物联合使用。
• NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS
  申请人：STEIN Gideon

  公开号：US20120277310A1

  公开（公告）日：2012-11-01

  A conjugate comprising L-DOPA covalently linked to at least one γ-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.

  本发明揭示了一种共轭物，包括L-DOPA与至少一种γ-氨基丁酸（GABA）基团共价连接，以及它的酯和/或加成盐，以及它们在治疗神经退行性疾病或障碍方面的用途。
• CONJUGATED PSYCHOTROPIC DRUGS AND USES THEREOF
  申请人：Nudelman Abraham

  公开号：US20120309748A1

  公开（公告）日：2012-12-06

  Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.

  本发明揭示了精神药物和有机酸的新型化学结合物，其用途包括治疗精神病和/或增生性疾病，作为化疗增敏剂，并且还揭示了它们的合成方法。所选有机酸被选择为减少精神药物引起的副作用和/或发挥抗增殖活性。