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    首页 分子通 12-Phenylmethoxy-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-2(8),9(17),10,12-tetraene

    12-Phenylmethoxy-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-2(8),9(17),10,12-tetraene

    分子结构分类

    有机化合物 - 有机杂环化合物 - Pyrroloazepines
    中文名称
    ——
    中文别名
    ——
    英文名称
    12-Phenylmethoxy-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-2(8),9(17),10,12-tetraene
    英文别名
    ——
    12-Phenylmethoxy-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-2(8),9(17),10,12-tetraene化学式
    CAS
    ——
    化学式
    C21H22N2O2
    mdl
    ——
    分子量
    334.4
    InChiKey
    UENIYSQTQWFHSS-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      3
    • 重原子数：
      25
    • 可旋转键数：
      3
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.33
    • 拓扑面积：
      35.4
    • 氢给体数：
      1
    • 氢受体数：
      3

    文献信息

    • Tetracyclic azepinoindole compounds
      申请人：PHARMACIA & UPJOHN COMPANY
      公开号：US20020198190A1
      公开（公告）日：2002-12-26
      The present invention provides compounds of formula I: 1 wherein R 1 , R 2 , X and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I).
      本发明提供了公式I的化合物：1其中R1、R2、X和Y的任何值均在规范中定义，以及包含该化合物的药物组合物。该发明还提供了治疗方法，以及用于制备公式（I）化合物的过程和中间体。
    • TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS
      申请人：PHARMACIA & UPJOHN COMPANY
      公开号：EP1173440B1
      公开（公告）日：2004-09-15
    • US6407092B1
      申请人：——
      公开号：US6407092B1
      公开（公告）日：2002-06-18
    • US6875762B2
      申请人：——
      公开号：US6875762B2
      公开（公告）日：2005-04-05
    • [EN] TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS<br/>[FR] COMPOSES D'AZEPINOINDOLE TETRACYCLIQUE UTILISES COMME LIGANDS RECEPTEURS DE 5-HT
      申请人：UPJOHN CO
      公开号：WO2000064899A1
      公开（公告）日：2000-11-02
      The present invention provides compounds of formula (I), wherein R2 is hydrogen, C1-7alkyl, C1-7alkanoyl, arylcarbonyl, aryl, (aryl)C1-7alkyl, C1-7alkoxycarbonyl, aryloxycarbonyl, arylsulfonyl, or (aryl)C1-7alkoxycarbonyl; X and Y together are 2, 3 or 4 membered saturated or partially unsaturated chain. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.
    查看更多

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