Disclosed are a PIVKA-II measurement method that achieves better serum-plasma correlation than conventional methods, and a reagent and a kit therefor. The PIVKA-II measurement method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using a mixture of an anti-F1 antibody that specifically binds to prothrombin fragment F1 or an antigen-binding fragment thereof and an anti-F2 antibody that specifically binds to prothrombin fragment F2 or an antigen-binding fragment thereof; and an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof.
本发明公开了一种
PIVKA-II 测量方法及其试剂和试剂盒,与传统方法相比,该方法可实现更好的血清-血浆相关性。根据本发明的
PIVKA-II 测量方法,包括通过免疫测定法测量样本中的
PIVKA-II,使用的混合物包括特异性结合凝血酶原片段 F1 或其抗原结合片段的抗 F1
抗体和特异性结合凝血酶原片段 F2 或其抗原结合片段的抗 F2
抗体;以及特异性结合
PIVKA-II 或其抗原结合片段的抗
PIVKA-II
抗体。