2-methacryloyloxyethyl phosphoryldimethyl ester | 61393-58-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2-methacryloyloxyethyl phosphoryldimethyl ester
• 英文别名: MPDME；2-[(Dimethoxyphosphoryl)oxy]ethyl 2-methylprop-2-enoate；2-dimethoxyphosphoryloxyethyl 2-methylprop-2-enoate
• CAS: 61393-58-6
• 化学式: C₈H₁₅O₆P
• 分子量: 238.177
• InChiKey: JEBFWGCXGMFKDJ-UHFFFAOYSA-N

物化性质

• 沸点：
  299.8±23.0 °C(Predicted)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 氯磷酸二甲酯 在 吡啶 作用下， 以 氯仿 为溶剂， 以81.1%的产率得到2-methacryloyloxyethyl phosphoryldimethyl ester
  参考文献：
  名称：

  Synthesis of biomembrane-mimic polymers with various phospholipid head groups

  摘要：

  Lipid bilayers in biomembranes consist of diverse phospholipids, including phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) with various compositions according to the cell and tissue types. We synthesized biomembrane-mimic polymers, poly(2-methacryloyloxyethyl phosphoric acid) (PMPA), poly(2-methacryloyloxyethyl phosphorylethanolamine) (PMPE), and poly(2-methacryloyloxyethyl phosphorylserine) (PMPS), with PA, PE, and PS head groups, respectively. PA monomer was synthesized from 2-hydroxyethyl methacrylate (HEMA) and dimethyl chlorophosphate (DCP). PE and PS monomers were synthesized from N-tert-butoxycarbonyl (tBoc) protected ethanolamine and serine through the reaction with 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP). Each biomembrane-mimic polymer was successfully synthesized by atom transfer radical polymerization (ATRP) from the monomer. The molecular weight distributions of PMPA, PMPE, and PMPS were analyzed by gel permeation chromatography (GPC) and in vitro cytotoxicity was also examined by 3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MU) and lactate dehydrogenase (LDH) assay. The new biomembrane-mimic polymers could be used to prepare a polymeric platform that mimic a cell- or tissue-specific membrane for future applications in biomedical fields such as tissue engineering or bioimplants. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2013.12.020

文献信息

• DISPERSING AGENT
  申请人：Toagosei Co., Ltd

  公开号：EP2025394A1

  公开（公告）日：2009-02-18

  To provide a dispersing agent that contains a water-soluble polymer that has excellent dispersibility and stability over time even for a high concentration of a dispersoid such as a pigment and can give a pigment slurry having stable viscosity characteristics and redispersibility due to a large dispersion stabilization effect. A dispersing agent containing a water-soluble polymer and/or an alkali metal salt or an ammonium salt of the water-soluble polymer, the water-soluble polymer containing (A) an ethylenically unsaturated monocarboxylic acid monomer or an anhydride thereof, or an ethylenically unsaturated dicarboxylic acid monomer or an anhydride thereof, and (B) a polyether compound, a ratio [(B)/(A)] of the number of moles of alkylene oxide added in component (B) relative to the number of moles of carboxyl group in component (A) being no greater than 0.6, and component (B) being less than 25 wt % relative to the total amount.

  为了提供一种含有水溶性聚合物的分散剂，该分散剂即使对高浓度的分散体（如颜料）也具有优异的分散性和长期稳定性，并且由于具有较大的分散稳定效果，可以得到具有稳定粘度特性和再分散性的颜料浆。 一种含有水溶性聚合物和/或该水溶性聚合物的碱金属盐或铵盐的分散剂，该水溶性聚合物含有 (A) 乙烯基不饱和单羧酸单体或其酸酐、或乙烯基不饱和二羧酸单体或其酸酐，以及 (B) 聚醚化合物，组分 (B) 中添加的氧化亚烷摩尔数与组分 (A) 中羧基摩尔数之比[(B)/(A)]不大于 0.6，而组分（B）相对于总量小于 25 wt%。
• Preparation of pH-sensitive CaP nanoparticles coated with a phosphate-based block copolymer for efficient gene delivery
  作者：Sangmok Jang、Seonju Lee、Heejin Kim、Jiyeon Ham、Ji-Hun Seo、Yeongbong Mok、Minwoo Noh、Yan Lee

  DOI：10.1016/j.polymer.2012.08.043

  日期：2012.9

  We have synthesized a phosphate-based block copolymer, PEG-b-PMOEP (poly(ethylene glycol)-b-poly(2-methacryloyloxyethyl phosphate)), with a narrow molecular weight distribution (PD = 1.06) by atomic transfer radical polymerization (ATRP), and have constructed calcium phosphate nanoparticles (CaPNs) coated with the block copolymer as an efficient and safe intracellular gene delivery carrier. The phosphate-mimic PMOEP block could be incorporated into the calcium phosphate (CaP) core to entrap pDNA, with the PEG block forming a shell to prevent uncontrolled growth of CaP precipitates and aggregates in physiological fluids. The CaPNs showed high colloidal stability at pH 7.4, but released entrapped pDNA at an endosomal pH of 5.0 through a pH-dependent protonation of phosphate moieties for efficient endosomal escape. The PEG-b-PMOEP/CaP/pDNA nanoparticles, which were formed simply by mixing, exhibited great potential as gene delivery carriers for future gene therapy applications due to their high transfection efficiency, low toxicity, and good stability under physiological conditions. (C) 2012 Elsevier Ltd. All rights reserved.
• THERMALLY CONDUCTIVE COMPOSITION
  申请人：3M Innovative Properties Company

  公开号：EP1773925A1

  公开（公告）日：2007-04-18
• THERMALLY CONDUCTIVE SHEET
  申请人：3M Innovative Properties Company

  公开号：EP1791874A1

  公开（公告）日：2007-06-06
• Thermally Conductive Sheet
  申请人：Yoda Masaki

  公开号：US20070224426A1

  公开（公告）日：2007-09-27

  There is provided a thermally conductive sheet containing: a binder component, a modified liquid polyolefin, and at least one thermally conductive filler selected from the group consisting of metal oxide and metal hydroxide. The thermally conductive sheet can have good moldability, and the surface of the sheet is inhibited from being contaminated by bleeding or the like. Further, the sheet can have good flexibility maintained for a long period of time and is inhibited from deteriorating or emitting an offensive odor due to decomposed matter of an organic phosphorous compound even when an organic phosphorous compound is contained.