3-O-myristoyl-D-glucopyranose | 73118-67-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: 3-O-myristoyl-D-glucopyranose
• 英文别名: (3R,4S,5R,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl tetradecanoate；3-O-Miristoyl-D-glucopyranose；[(3R,4S,5R,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)oxan-4-yl] tetradecanoate
• CAS: 73118-67-9；73118-91-9
• 化学式: C₂₀H₃₈O₇
• 分子量: 390.518
• InChiKey: DANAXJFLDPDUNC-MZSJESITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-O-myristoyl-D-glucopyranose 反应 0.17h， 生成 6-O-tetradecanoyl-α-D-glucopyranoside 、 6-O-myristoyl-D-glucose 、 2-O-Myristoyl-D-glucopyranose
  参考文献：
  名称：

  General path of O-acyl migration in d-glucose derivatives

  摘要：

  DOI：

  10.1016/s0008-6215(00)85219-2
• 作为产物：
  描述：

  6-O-tetradecanoyl-α-D-glucopyranoside 反应 0.17h， 生成 6-O-myristoyl-D-glucose 、 3-O-myristoyl-D-glucopyranose
  参考文献：
  名称：

  General path of O-acyl migration in d-glucose derivatives

  摘要：

  DOI：

  10.1016/s0008-6215(00)85219-2

文献信息

• MONOSACCHARIDE-BASED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DERMATOLOGICAL DISEASES
  申请人：The University of Texas M.D. Anderson Cancer

  公开号：EP2663314A2

  公开（公告）日：2013-11-20
• [EN] MONOSACCHARIDE-BASED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DERMATOLOGICAL DISEASES<br/>[FR] COMPOSÉS À BASE DE MONOSACCHARIDES POUR LE TRAITEMENT DE MALADIES DERMATOLOGIQUES PROLIFÉRATIVES ET INFLAMMATOIRES
  申请人：INTERTECH BIO LLC

  公开号：WO2012097052A2

  公开（公告）日：2012-07-19

  The present invention relates to compounds and methods which may be useful as inhibitors of glycolysis, inhibitors of protein glycosylation, anti-virals, and down-regulators of insulin receptor and IGF- 1 receptor for the treatment or prevention of inflammatory dermatological diseases or proliferative dermatological diseases.
• [EN] METHOD OF TREATING VIRAL INFECTIONS WITH HEXOSE TYPE MONOSACCHARIDES AND ANALOGS THEREOF<br/>[FR] PROCÉDÉ DE TRAITEMENT D'INFECTIONS VIRALES AVEC DES MONOSACCHARIDES DE TYPE HEXOSES ET LEURS ANALOGUES
  申请人：UNIV TEXAS

  公开号：WO2021188586A1

  公开（公告）日：2021-09-23

  The present invention relates to methods of treating and preventing viral diseases and infections comprising the administration of hexoses and analogs and their prodrugs thereof that inhibit glycolysis and/or glycosylation.
• General path of O-acyl migration in d-glucose derivatives
  作者：Yoshisuke Tsuda、Kimihiro Yoshimoto

  DOI：10.1016/s0008-6215(00)85219-2

  日期：1980.12