Dipropyl-diethylphosphoramidat | 22250-42-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Dipropyl-diethylphosphoramidat
• 英文别名: O,O-Dipropyl N,N-diethyl phosphoramidate；N-dipropoxyphosphoryl-N-ethylethanamine
• CAS: 22250-42-6
• 化学式: C₁₀H₂₄NO₃P
• 分子量: 237.279
• InChiKey: GCWJZBQAMIOLHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Dipropyl-diethylphosphoramidat 以 乙醚 为溶剂， 生成 Phosphorigsaeure-dipropylester-(2-acetoxy-1,2-diphenyl-vinylester)
  参考文献：
  名称：

  Evdakov,V.P. et al., Journal of General Chemistry of the USSR, 1967, vol. 37, # 8, p. 1733 - 1735

  摘要：

  DOI：
• 作为产物：
  描述：

  diethyl-phosphoramidous acid dipropyl ester 在 丙酮酸甲酯 作用下， 生成 Dipropyl-diethylphosphoramidat
  参考文献：
  名称：

  Pudovik,A.N. et al., Journal of general chemistry of the USSR, 1969, vol. 39, # 2, p. 317 - 319

  摘要：

  DOI：

文献信息

• N,N′-Dichlorobis(2,4,6-trichlorophenyl)urea (CC-2): an Efficient Reagent for the Synthesis of Chemical Weapons Convention-Related Dialkyl-N,N-dialkylphosphoramidates from Dialkylphosphites
  作者：Arvind K. Gupta、Deepak Pardasani、Hemendra K. Gupta、Devendra K. Dubey

  DOI：10.1071/ch07081

  日期：——

  The present paper describes the one-pot synthesis of dialkyl N,N-dialkylphosphoramidates (DADAP) from dialkylphosphites and dialkylamines using N,N′-dichlorobis(2,4,6-trichlorophenyl)urea (CC-2) as chlorinating reagent. DADAP belong to the schedule 2.B.6 category of the Chemical Weapons Convention (CWC), as they are the important markers of the chemical warfare agent tabun and its analogues. The study was undertaken to develop the spectral database of DADAP for verification of CWC. The reported synthetic strategy can be adopted to rapidly synthesize several analogues of DADAP during official proficiency tests.

  本文介绍了以 N,N′-二氯双(2,4,6-三氯苯基)脲（CC-2）为氯化试剂，从二烷基亚磷酸盐和二烷基胺中一步合成 N,N-二烷基磷酰胺酸二烷基酯（DADAP）的方法。DADAP 属于《化学武器公约》附表 2.B.6，是化学战剂塔崩及其类似物的重要标记。这项研究旨在开发 DADAP 的光谱数据库，用于《化学武器公约》的核查。所报告的合成策略可用于在官方能力测试中快速合成多种 DADAP 类似物。
• A single-step one pot synthesis of O,O′-dialkyl N,N-dialkylphosphoramidates from dialkylphosphites
  作者：Ajay Kumar Purohit、Deepak Pardasani、Ajeet Kumar、D. Raghavender Goud、Rajiv Jain、D.K. Dubey

  DOI：10.1016/j.tetlet.2016.07.019

  日期：2016.8

  An efficient synthetic method has been developed to obtain chemical weapons convention (CWC)-related O,O′-dialkyl-N,N-dialkylphosphoramidates from dialkylphosphites using inorganic reagents (CuCl2 and Cs2CO3) at room temperature.

  一种有效的合成方法已被开发，以获得化学武器公约（CWC）相关ø，ö ' -二烷基ñ，ñ使用无机试剂（氯化亚铜dialkylphosphites -dialkylphosphoramidates 2和Cs 2 CO 3）在室温下。
• Dichlorodimethyl Hydantoin: An Efficient Reagent for One-Pot Synthesis of CWC-Related O,O-dialkyl, N,N-dialkyl Phosphoramidates
  作者：Arvind K. Gupta、Devendra K. Dubey、M. P. Kaushik

  DOI：10.1080/10426500701724514

  日期：2008.6.9

  A simple, rapid, economical, and efficient one-pot synthetic method for preparation of O,O-dialkyl, N,N-dialkylphosphoramidates (DADAPs) and phosphates has been developed.

  开发了一种简单、快速、经济、高效的一锅合成方法，用于制备 O,O-二烷基、N,N-二烷基氨基磷酸酯 (DADAPs) 和磷酸盐。
• Pudovik,A.N. et al., Journal of general chemistry of the USSR, 1969, vol. 39, # 2, p. 317 - 319
  作者：Pudovik,A.N. et al.

  DOI：——

  日期：——
• Nifant'ev,E.E.; Shilov,I.V., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2398 - 2400
  作者：Nifant'ev,E.E.、Shilov,I.V.

  DOI：——

  日期：——