Diaethyl-N-o-chlorphenylphosphoramidat | 6345-18-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Diaethyl-N-o-chlorphenylphosphoramidat
• 英文别名: Diethyl(2-chlorophenyl)phosphoramidate；2-chloro-N-diethoxyphosphorylaniline
• CAS: 6345-18-2
• 化学式: C₁₀H₁₅ClNO₃P
• 分子量: 263.661
• InChiKey: KEYVUNMUTNFRNB-UHFFFAOYSA-N

物化性质

• 沸点：
  314.8±44.0 °C(Predicted)
• 密度：
  1.272±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  亚磷酸二乙酯 、 邻氯苯胺 在 碘 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 以43%的产率得到Diaethyl-N-o-chlorphenylphosphoramidat
  参考文献：
  名称：

  Iodine catalyzed solvent-free cross-dehydrogenative coupling of arylamines and H-phosphonates for the synthesis of N-arylphosphoramidates under atmospheric conditions

  摘要：

  Aerobic oxidative coupling of various arylamines and H-phosphonates to the corresponding N-arylphosphoramidates has been achieved under solvent-free conditions using molecular iodine. This protocol works at room temperature furnishing the corresponding P-N coupling products in moderate to high yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.064

文献信息

• KIRILOV, M.;PETROVA, J.;VASSILEVA, M.;IVANOVA, E.;MOMCHILOVA, S., IZV. XIM. BAN, 1981, 14, N 1, 40-48
  作者：KIRILOV, M.、PETROVA, J.、VASSILEVA, M.、IVANOVA, E.、MOMCHILOVA, S.

  DOI：——

  日期：——
• Iodine catalyzed solvent-free cross-dehydrogenative coupling of arylamines and H-phosphonates for the synthesis of N-arylphosphoramidates under atmospheric conditions
  作者：Bashir Ahmad Dar、Nisar A. Dangroo、Amit Gupta、Aarti Wali、Mohammad Akbar Khuroo、Ram A. Vishwakarma、Baldev Singh

  DOI：10.1016/j.tetlet.2014.01.064

  日期：2014.2

  Aerobic oxidative coupling of various arylamines and H-phosphonates to the corresponding N-arylphosphoramidates has been achieved under solvent-free conditions using molecular iodine. This protocol works at room temperature furnishing the corresponding P-N coupling products in moderate to high yields. (C) 2014 Elsevier Ltd. All rights reserved.