Bis-triethylammonium phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Bis-triethylammonium phosphate
• 英文别名: hydrogen phosphate;triethylazanium
• 化学式: C12H33N2O4P
• 分子量: 300.38
• InChiKey: DXZHTHGGEKOSBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.77
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PROCESS FOR TRIPHOSPHATE OLIGONUCLEOTIDE SYNTHESIS<br/>[FR] PROCÉDÉ POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES TRIPHOSPHATES
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2011028218A1

  公开（公告）日：2011-03-10

  The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5'-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5 '-triphosphate oligonucleotide synthesis.

  本发明描述了一种简单、高效且无酶的制备5'-三磷酸寡核苷酸的方法。本发明提出了一种使用二芳基膦酸酯作为试剂合成三磷酸寡核苷酸的新型方法。本发明的方法适用于大规模、经济的5'-三磷酸寡核苷酸合成。
• ISOPRENOIDS AND METHODS OF MAKING THEREOF
  申请人：NORTH CAROLINA STATE UNIVERSITY

  公开号：US20220162188A1

  公开（公告）日：2022-05-26

  Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

  本发明公开了制备异戊二烯基亚基的方法，以及利用这些异戊二烯基亚基合成异戊二烯类化合物的方法。还提供了使用本发明所述方法制备的异戊二烯类化合物。
• N,N-DISUBSTITUTED AMIC ACID DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0805154A1

  公开（公告）日：1997-11-05

  The present invention relates to a compound of the formula (I): wherein Ar1, Ar2, Ar3 and Ar4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; X and Y represent an oxygen atom, a sulfur atom, a carbonyl group or a group of the formula -CHRa- (wherein Ra is a hydrogen atom or a lower alkyl group) or -NRb- (wherein Rb is a hydrogen atom or a lower alkyl group), or X and Y together represent a vinylene group or an ethynylene group; R1, R2, R3, R8 and R9 represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a lower alkoxy group; R4 and R5 represent a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a lower alkyl group, a lower hydroxyalkyl group, a lower fluoroalkyl group or a lower alkoxy group; R6 is a lower alkyl group; and R7 is a hydrogen atom or a lower alkyl group, provided that when one of X and Y is an oxygen atom, a sulfur atom or a group of the formula -NRb-, the other is a carbonyl group or a group of the formula -CHRa-, its pharmaceutically acceptable salt or ester, and an antitumor agent containing it as an active ingredient.

  本发明涉及一种式（I）化合物： 其中 Ar1、Ar2、Ar3 和 Ar4 代表芳基或杂芳环基团；A 代表可被取代的烃基；X和Y代表氧原子、硫原子、羰基或式-CHRa-（其中Ra为氢原子或低级烷基）或-NRb-（其中Rb为氢原子或低级烷基）的基团，或X和Y共同代表乙烯基或乙炔基； R1、R2、R3、R8和R9代表氢原子、卤素原子、羟基、低级烷基或低级烷氧基；R4 和 R5 代表氢原子、卤素原子、羟基、氨基、硝基、氰基、羧基、低级烷氧基羰基、氨基甲酰基、低级烷基氨基甲酰基、低级烷基、低级羟烷基、低级氟烷基或低级烷氧基； R6 是低级烷基；和 R7 是氢原子或低级烷基，条件是当 X 和 Y 中的一个是氧原子、硫原子或式 -NRb- 的基团时，另一个是羰基或式 -CHRa- 的基团、其药学上可接受的盐或酯，以及含有它作为活性成分的抗肿瘤剂。
• CYCLIC AMIC ACID DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0882703A1

  公开（公告）日：1998-12-09

  The present invention relates to a compound of the formula (I), or its pharmaceutically acceptable salt or ester: wherein Ar1 is an aryl group or a heteroaromatic ring group; Ar is a group of the formula each of Ar2 and Ar3 is an aryl group or a heteroaromatic ring group; Cy is an aryl group, a heteroaromatic ring group or an aliphatic ring group which may contain one or two oxygen atoms; A1 is a C1-4 chain hydrocarbon group; m is an integer of from 1 to 6; each of n and p is an integer of from 0 to 3; Q1 is a single bond, a group of the formula -CH2O-, -OCH2-, -CH2S- or -SCH2-, or a C1-6 chain hydrocarbon group; Q2 is a single bond or a group of the formula -(CH2)m- or -(CH2)n-W-(CH2)p-; Q3 is a single bond, an oxygen atom, a sulfur atom, a methylene group, a vinylene group or a group of the formula -CO-, -NH-, -COO-, -OCO-, -CH2CH2-, -OCH2-, -SCH2-, -CH2O-, -CH2S-, -NHCO- or -CONH-; R1 is a lower alkyl group; each of R2 and R3 is a hydrogen atom, a hydroxyl group or a lower alkyl group; W is an oxygen atom, a sulfur atom, a vinylene group or an ethynylene group; x is an integer of from 0 to 2; and y is 0 or 1; and an antitumor agent containing it as an active ingredient and intermediates for the production thereof.

  本发明涉及式（I）化合物或其药学上可接受的盐或酯： 其中 Ar1 是芳基或杂芳环基；Ar 是式中的一个基团 Ar2 和 Ar3 各为芳基或杂芳环基团； Cy 为芳基、杂芳环基团或脂肪族环基团，可包含一个或两个氧原子； A1 为 C1-4 链烃基团； m 为 1-6 之间的整数；n 和 p 各为 0 至 3 的整数； Q1 是单键、式-CH2O-、-OCH2-、-CH2S- 或-SCH2-的基团或 C1-6 链烃基； Q2 是单键或式-(CH2)m- 或-(CH2)n-W-(CH2)p-的基团；Q3是单键、氧原子、硫原子、亚甲基、亚乙烯基或式-CO-、-NH-、-COO-、-OCO-、-CH2CH2-、-OCH2-、-SCH2-、-CH2O-、-CH2S-、-NHCO-或-CONH-的基团；R1是低级烷基；R2和R3各自是氢原子、羟基或低级烷基；W 是氧原子、硫原子、乙烯基或乙炔基； x 是 0 至 2 的整数； y 是 0 或 1；以及含有它作为活性成分的抗肿瘤剂及其生产中间体。
• SUBSTITUTED AMIDE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0882701A1

  公开（公告）日：1998-12-09

  Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, and antitumor agents comprising these as the active ingredients, wherein Ar1, Ar2, and Ar3 each represents aryl or heteroaryl; A1 represents C1-6 hydrocarbyl or a group represented by -A1a-W1-A1b- (where W1 represents oxygen, sulfur, ethynylene, cyclopropylene, or a group represented by -NRw-); A2 represents C1-8 hydrocarbyl group; R1 represents lower alkyl, lower alkenyl, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, a group represented by RaCOO- (where Ra represents hydrogen, amino, lower alkyl, lower alkoxy, or lower alkylamino) or by RbCONRc- (where Rb represents hydrogen, amino, lower alkyl, lower alkoxy, or lower alkylamino), or an alicyclic group; R2 represents lower alkyl; and X and Y each represents oxygen, sulfur, carbonyl, or a group represented by -CHRd- or -NRc-, or X and Y are bonded to each other to thereby form vinylene or ethynylene, provided that when one of X and Y represents oxygen, sulfur, or a group represented by -NRc-, then the other represents carbonyl or a group represented by -CHRd-.

  通式(I)所代表的化合物、其药理学上可接受的盐或酯以及抗肿瘤剂，包括 其中 Ar1、Ar2 和 Ar3 各自代表芳基或杂芳基；A1 代表 C1-6 烃基或由 -A1a-W1-A1b- 代表的基团（其中 W1 代表氧、硫、乙炔基、环丙烯基或由 -NRw- 代表的基团）；A2 代表 C1-8 烃基；R1 代表低级烷基、低级烯基、低级烷氧基、羧基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基、RaCOO-（其中 Ra 代表氢、氨基、低级烷基、低级烷氧基或低级烷基氨基）或 RbCONRc-（其中 Rb 代表氢、氨基、低级烷基、低级烷氧基或低级烷基氨基）所代表的基团或脂环族基团；R2 代表低级烷基；以及 X 和 Y 各自代表氧、硫、羰基或由 -CHRd- 或 -NRc- 所代表的基团，或 X 和 Y 相互键合从而形成乙烯基或乙炔基，条件是当 X 和 Y 中的一个代表氧、硫或由 -NRc- 所代表的基团时，另一个代表羰基或由 -CHRd- 所代表的基团。