1,1,3,3-Tetraethyl-2-[fluoro(methoxy)phosphoryl]guanidine | 2422944-38-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 1,1,3,3-Tetraethyl-2-[fluoro(methoxy)phosphoryl]guanidine
• CAS: 2422944-38-3
• 化学式: C₁₀H₂₃FN₃O₂P
• 分子量: 267.28
• InChiKey: AEQJLRXTEIZQBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] METHOD OF DETECTION<br/>[FR] PROCÉDÉ DE DÉTECTION
  申请人：UNIV QUEENSLAND

  公开号：WO2021189112A1

  公开（公告）日：2021-09-30

  A method for detection of a nerve agent in a sample, which method comprises (a) irradiating an optical sensing element, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, and measuring the luminescence of the optical sensing element; wherein the fluorescent sensing compound comprises a combination of at least one electron acceptor moiety and, optionally, one or more electron donor moieties such that the electronic properties of the sensing compound are sufficient to enable a change in the luminescence of the sensing element in the presence of the nerve agent, and a moiety that influences solubility of the sensing compound in a solvent; (b) contacting the sample with the optical sensing element; (c) measuring the luminescence of the optical sensing element; and (d) determining whether the nerve agent is present in the sample based on the measurements obtained in steps (a) and (c).

  一种检测样品中神经毒剂的方法，该方法包括：（a）照射光学传感元件，光学传感元件包括提供在基底上的荧光感应化合物，并测量光学传感元件的发光度；其中，荧光感应化合物包括至少一个电子受体基团的组合，以及可选地一个或多个电子给体基团，使得感应化合物的电子性质足以在神经毒剂存在时改变感应元件的发光度，并且影响感应化合物在溶剂中的溶解度的基团；（b）将样品与光学传感元件接触；（c）测量光学传感元件的发光度；以及（d）根据步骤（a）和（c）得到的测量结果确定样品中是否存在神经毒剂。
• [EN] DETECTION METHOD<br/>[FR] PROCÉDÉ DE DÉTECTION
  申请人：[en]THE UNIVERSITY OF QUEENSLAND

  公开号：WO2022104414A1

  公开（公告）日：2022-05-27

  The disclosure relates to a method for detecting a nerve agent in an analyte, said nerve agent having a phosphorus-fluorine bond, which method comprises: (a) contacting the analyte with a solid state composition comprising a sensor compound; wherein the sensor compound comprises a basic nitrogen atom and a hydroxyaryl moiety protected by a silyl protecting group; and wherein, in the presence of hydrogen fluoride, said silyl group is cleaved to effect deprotection of the hydroxyl group thus forming a luminescent reporter compound; (b) irradiating the solid state composition at a predetermined wavelength; (c) measuring the luminescence to determine if the reporter compound is present; and (d) determining whether the nerve agent is present in the analyte based on the measurement obtained in step (c).