Decyl 6-(dodecyldimethylammonio)hexyl phosphate | 1201798-06-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Decyl 6-(dodecyldimethylammonio)hexyl phosphate
• 英文别名: decyl 6-[dodecyl(dimethyl)azaniumyl]hexyl phosphate
• CAS: 1201798-06-2
• 化学式: C₃₀H₆₄NO₄P
• 分子量: 533.816
• InChiKey: GEZLOKYBEJLVFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  36
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  n-Decyl phosphorodichloridate 、 N-(6-hydroxyhexyl)-N,N-dimethyldodecan-1-aminium 4-methylbenzenesulfonate 在 吡啶 、 水 作用下， 生成 Decyl 6-(dodecyldimethylammonio)hexyl phosphate
  参考文献：
  名称：

  Synthesis and biological activity of dialkylphosphocholines

  摘要：

  A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.079

文献信息

• Synthesis and biological activity of dialkylphosphocholines
  作者：Miloš Lukáč、Martin Mrva、Eva Fischer-Fodor、Ivan Lacko、Marián Bukovský、Natalia Miklášová、František Ondriska、Ferdinand Devínsky

  DOI：10.1016/j.bmcl.2009.09.079

  日期：2009.11

  A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells. (C) 2009 Elsevier Ltd. All rights reserved.