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    首页 分子通 4,5-dichloro-N-[3-(2-chloro-6-fluorophenyl)-1,2,4-thiadiazol-5-yl]thiophene-2-sulfonamide

    4,5-dichloro-N-[3-(2-chloro-6-fluorophenyl)-1,2,4-thiadiazol-5-yl]thiophene-2-sulfonamide | 531552-17-7

    分子结构分类

    有机化合物 - 有机杂环化合物 - 噻吩并噻唑类
    中文名称
    ——
    中文别名
    ——
    英文名称
    4,5-dichloro-N-[3-(2-chloro-6-fluorophenyl)-1,2,4-thiadiazol-5-yl]thiophene-2-sulfonamide
    英文别名
    ——
    4,5-dichloro-N-[3-(2-chloro-6-fluorophenyl)-1,2,4-thiadiazol-5-yl]thiophene-2-sulfonamide化学式
    CAS
    531552-17-7
    化学式
    C12H5Cl3FN3O2S3
    mdl
    ——
    分子量
    444.746
    InChiKey
    MCKAIXUBKZSNOF-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      5.6
    • 重原子数：
      24
    • 可旋转键数：
      4
    • 环数：
      3.0
    • sp3杂化的碳原子比例：
      0.0
    • 拓扑面积：
      137
    • 氢给体数：
      1
    • 氢受体数：
      8

    文献信息

    • Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
      申请人：——
      公开号：US20030130258A1
      公开（公告）日：2003-07-10
      The present invention relates to compounds with the formula (I) 1 and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-&bgr;-hydroxysteroid dehydrogenase type 1 enzyme.
      本发明涉及式 (I) 的化合物 1 以及包含这些化合物的药物组合物，还涉及这些化合物在医药中的用途和制备对人类 11-&bgr;- 羟基类固醇脱氢酶 1 型酶起作用的药物。
    • INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
      申请人：BIOVITRUM AB
      公开号：EP1461327A1
      公开（公告）日：2004-09-29
    • US7074788B2
      申请人：——
      公开号：US7074788B2
      公开（公告）日：2006-07-11
    • [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1
      申请人：BIOVITRUM AB
      公开号：WO2003044000A1
      公开（公告）日：2003-05-30
      The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.
    • [EN] USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING<br/>[FR] UTILISATION D'UN INHIBITEUR DE COMPOSE DE TYPE 1 11-B-HYDROXYSTEROIDE DESHYDROGENASE TYPE 1 DESTINE A FACILITER LA CICATRISATION D'UNE PLAIE
      申请人：BIOVITRUM AB
      公开号：WO2004113310A1
      公开（公告）日：2004-12-29
      The invention relates to a method for promoting wound healing, said method comprising administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-ß-hydroxysteroid dehydrogenase type 1 wherein the said l lß-HSD1 inhibitor has the formula (I) wherein T, R1, A1 and A2 are as defined in the specification. These compounds may also be used in the manufacture of a medicament for promoting wound healing.
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    同类化合物

    噻吩并[3,2-d]异噻唑-5-羧酸乙酯 5-苯基-3-(1H-吡唑-1-基)噻吩并[2,3-d]异噻唑1,1-二氧化 4-氯-8-(甲基硫烷基)异噻唑并[4',5':4,5]噻吩并[3,2-d][1,2,3]三嗪 4-氨基-3-甲硫基噻吩并[4,5-d][1,2]噻唑-5-甲酰胺 4-氨基-3-甲基噻吩并[2,3-c]异噻唑-5-羧酸乙酯 4-氨基-3-[(4-氟苯甲基)硫烷基]噻吩并[2,3-c]异噻唑-5-甲酰胺 4-[2-(6-甲氧基萘-2-基)丙基]-N-甲基哌嗪-1-甲酰胺 4,6-二氢噻吩并[3,4-d][1,3]噻唑5,5-二氧化物 3-甲基噻吩并[2,3-c]异噻唑-5-羧酸乙酯 3-(4-氯-3,5-二甲基-1H-吡唑-1-基)噻吩并[3,4-d]异噻唑1,1-二氧化 3-(4-氯-1H-吡唑-1-基)噻吩并[3,4-d]异噻唑1,1-二氧化 3-(3,5-二甲基吡唑-1-基)噻吩并[3,4-d][1,2]噻唑1,1-二氧化物 2-甲基噻吩并噻唑 2-甲基噻吩并[2,3-d]异噻唑-3(2H)-酮 1,1-二氧化物 2-氨基噻吩并[2,3-d]噻唑-6-羧酸 甲酯 2-氨基噻吩并[2,3-D]噻唑 1,1-二氧代噻吩并[2,3-D]异噻唑-3-酮 (9CI)-2-氨基-噻吩并[2,3-d]噻唑-5-羧酸 2-[[1-Oxo-2-[6-(trifluoromethyl)pyridin-3-yl]-1,2-thiazolidin-1-ylidene]amino]-1,3-thiazol-4-one 6-cyano-2-ethyl-5-(trimethylsilyl)thieno[2,3-b]pyridine methyl 5-(1-methoxy-2-methylpropyl)-2,2'-bisthiazole-4-carboxylate 5-(2-methylpropen-1-yl)-2,2'-bisthiazole-4-carboxylic acid N-tert-Butyl-S-(4-chloro-isothiazolo[4,5-d]isothiazol-3-yl)-thiohydroxylamine ethyl 2-oxo-5-chloro-6-phenyl-3-benzothiazolineacetate 2-Hydroxy-5-phenylthieno<2,3-d>thiazol 1,1-dioxo-5-phenyl-1λ6-[1,4,2]dithiazinane-3-thione 1,1-dioxo-5-p-tolyl-1λ6-[1,4,2]dithiazinane-3-thione 5-phenyl-thieno[2,3-d]thiazol-2-ylamine 4-amino-1λ6,2-thiazinane-1,1-dione hydrochloride 4-(2,2-dioxo-2,3,3a,9a-tetrahydro-1H-2λ6-benzo[b]thieno[3,4-e][1,4]thiazin-9-yl)-butylamine 3-Propyl-4,6-dihydro-thieno[3,4-d]isothiazole 5,5-dioxide 4,5-dichloro-N-[3-(2-chloro-6-fluorophenyl)-1,2,4-thiadiazol-5-yl]thiophene-2-sulfonamide ethyl 6-N-formylaminothieno<2,3-d>thiazole-5-carboxylate 3,5-dichloro-thieno[3,2-b]thiophene-2-carboxylic acid 3-morpholin-4-yl-propylamide 7-acetyl-3,4,8-triamino-1H-pyrazolo<3,4-d>thieno<2,3-b>pyridin Methyl2-aminothieno[2,3-d][1,3]thiazole-5-carboxylatehydrochloride (3aR,6aR)-3-Benzyl-5,5-dioxo-hexahydro-5λ6-thieno[3,4-d]thiazol-2-ylideneamine; hydrobromide ethyl 3,5-dimethylthieno[3,2-c]diazepine-1-carboxylate 3,5-dimethyl-2-(4-methyl-thiazol-2-ylmethyl)-2H-[1,2]thiazine 1,1-dioxide 3-Methylthio-7-amino-isothiazolo<3',4':2,3>thieno<2,3-c>pyrimidin 13-Isobutyl-5.11-imino-5H.11H-dipyrido<2.3-b:2'.3'-f><1.5>dithiocin K-(4-Amino-3-methylthio-thieno<2,3-c>isothiazol-5)-carboxylat SN56 ethyl 4-amino-3-methylthiothieno<3,2-d>isothiazole-5-carboxylate 3-methyl-4-(3-methyl-5-phenylthiophen-2-yl)-4H-pyrimidine;hydrochloride 2-(Dimethylamino)thieno[2,3-d][1,3]thiazole-5-carboxylic acid 7-Bromothieno[3,2-c]pyridine-2-carboxylic acid 2,3-Dihydro-2-methyl-3-thioxo-thieno<3,4-d>isothiazol-1,1-dioxid

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