3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮 | 231630-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并咪唑类
• 中文名称: 3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮
• 英文名称: 3-methyl-2,3-dihydro-1H-thieno[2,3-d]imidazol-2-one
• 英文别名: 3-Methyl-1H-thieno[2,3-d]imidazol-2(3H)-one；3-methyl-1H-thieno[2,3-d]imidazol-2-one
• CAS: 231630-13-0
• 化学式: C₆H₆N₂OS
• 分子量: 154.192
• InChiKey: CZLSEXFVHQKUKI-UHFFFAOYSA-N

物化性质

• 密度：
  1.381±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  2-methylaminothiophene-3-carbonylazide 以 甲苯 为溶剂， 反应 5.0h， 以84%的产率得到3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮
  参考文献：
  名称：

  Efficient synthesis of N1- or N3-substituted thieno[2,3-d]imidazol-2-ones

  摘要：

  N-1- or N-3-substituted thieno[2,3-d]imidazol-2-one derivatives are selectively obtained after N-alkylation of thiaisatoic anhydrides followed by formation of the N-substituted aminocarbonyl azides and Curtius rearrangement, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00285-9

文献信息

• [EN] THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE THIAZOLE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2009058728A1

  公开（公告）日：2009-05-07

  The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

  本发明涉及新型噻唑衍生物，包含该噻唑衍生物的组合物，以及使用该噻唑衍生物治疗或预防增生性疾病、抗增生性疾病、炎症、关节炎、中枢神经系统疾病、心血管疾病、脱发、神经疾病、缺血性损伤、病毒感染、真菌感染或与蛋白激酶活性相关的疾病的方法。
• [EN] TRPA1 MODULATORS<br/>[FR] MODULATEURS DE TRPA1
  申请人：ALGOMEDIX INC

  公开号：WO2015103060A1

  公开（公告）日：2015-07-09

  This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.

  这份披露涉及到多环杂芳化合物，这些化合物可用作TRPA1调节剂，以及包括这些化合物的用于治疗疼痛的组合物和方法。
• Thiazole Derivatives as Protein Kinase Inhibitors
  申请人：Reddy Panduranga Adulla P.

  公开号：US20100331313A1

  公开（公告）日：2010-12-30

  The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
• TRPA1 MODULATORS
  申请人：Algomedix, Inc.

  公开号：US20170001983A1

  公开（公告）日：2017-01-05

  This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.
• US8476278B2
  申请人：——

  公开号：US8476278B2

  公开（公告）日：2013-07-02