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    首页 分子通 2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid

    2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid | 881888-42-2

    分子结构分类

    有机化合物 - 有机杂环化合物 - 噻吩并咪唑类
    中文名称
    ——
    中文别名
    ——
    英文名称
    2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid
    英文别名
    2-bromo-4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
    2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid化学式
    CAS
    881888-42-2
    化学式
    C6H3BrN2O2S
    mdl
    ——
    分子量
    247.07
    InChiKey
    SVIVRHLPLTZAAE-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      2.4
    • 重原子数：
      12
    • 可旋转键数：
      1
    • 环数：
      2.0
    • sp3杂化的碳原子比例：
      0.0
    • 拓扑面积：
      94.2
    • 氢给体数：
      2
    • 氢受体数：
      4

    文献信息

    • SUBSTITUTED THIENOPYRROLE CARBOXYLIC ACID AMIDES, PYRROLOTHIAZOLE CARBOXYLIC ACID AMIDES, AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
      申请人：Fink Marc David
      公开号：US20070299112A1
      公开（公告）日：2007-12-27
      The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.
      本发明揭示和声明公式(I)和公式(II)的化合物，作为人类酪蛋白激酶Iε的抑制剂，并提供使用这些化合物治疗中枢神经系统疾病和紊乱，包括情绪障碍和睡眠障碍的方法。还揭示和声明了包含公式(I)或公式(II)化合物的药物组合物，以及制备公式(I)或公式(II)化合物的方法。
    • US7393867B2
      申请人：——
      公开号：US7393867B2
      公开（公告）日：2008-07-01
    • US7652046B2
      申请人：——
      公开号：US7652046B2
      公开（公告）日：2010-01-26
    查看更多

    同类化合物

    沙维拉唑 4H-吡咯并[1,2-a]噻吩并[3,2-D]咪唑 3H-噻吩并[2,3-d]咪唑-5-羧酸 3-甲基-1H-噻吩并[2,3-d]咪唑-2(3h)-酮 2-(氯甲基)-1H-噻吩并[3,4-d]咪唑 1H-噻吩并[3,2-D]咪唑-2(3H)-酮 1H-噻吩并[2,3-d]咪唑,1-乙烯基-(9CI) 1H-噻吩并(3,4-d)咪唑,2-(((5-甲基-2-吡啶基)甲基)亚硫酰基)- 1-甲基-1H-噻吩并[2,3-D]咪唑基-2(3H)-酮 1-乙烯基-1H-噻吩并[2,3-d]咪唑-5-羧酸 1,3-二氢噻吩并[3,4-d]咪唑-2-硫酮 2-(3-Chloro-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(1-isopropyl-pyrrolo[3,2-b]pyridin-5-yl)-4-methyl-1,3-thiazole-5-carboxylic acid isopropyl ester 2-(3-cyano-1-isopropyl-pyrrolo[3,2-b]pyridin-5-yl)-4-methyl-1,3-thiazole-5-carboxylic acid isopropyl ester 2-(5-Methoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-(4-ethoxy-benzyl)-1(3)H-thieno[2,3-d]imidazole 3,4,8-triamino-1H-pyrazolo<3,4-d>thieno<2,3-b>pyridin-7-carbonsaeure-ethylester 1-[2-(5-Methyl-pyridin-2-ylmethanesulfinyl)-3H-thieno[3,4-d]imidazol-6-yl]-ethanone 2-Oxo-2,3-dihydro-4-methyl-1H-thieno<3,4-d>imidazol 2-[4-(2,2,2-trifluoroethyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 1,2-dimethyl-N-{2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]ethyl}-1H-thieno[3, 4-d]imidazole-4-carboxamide 2-[4-(2,2,3,3,3-pentafluoropropyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-(3-Fluoro-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-[(3-methoxypyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole 2-(5-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrobromide 2-(3,5-Dimethyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride ethyl 6-ethyl-1-methyl-3-(1-methylethoxy)-5-[(thiophen-2-ylcarbonyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate 1H-thieno[3,4-d]imidazol-2(3H)-one 2-(4-piperidino-3-chloro-2-picolylmercapto)-1H-thieno[3,4-d]imidazole 4,6-Dimethyl-2-(pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-(3-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride ethyl 2-benzylthio-1-methoxymethyl-1H-thieno<2,3-d>imidazole-5-carboxylate 2-(6-Methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-(4-Methoxy-pyridin-2-ylmethylsulfanyl)-4,6-dimethyl-1H-thieno[3,4-d]imidazole; hydrochloride 2-(4-Ethoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole; hydrochloride 2-[(3-methylpyridin-2-yl)methylsulfanyl]-1H-thieno[3,4-d]imidazole Methyl 2-oxo-1,3-dihydrothieno[3,4-d]imidazole-4-carboxylate 2-oxo-2,3-dihydro-4-(δ-N-methylcarbamidobutyl)-1H-thieno<3,4-d>imidazole methyl 2-hexylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate methyl 2-butylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate dimethyl 4-methyl-4H-pyrrolo[3,2-d][1,3]thiazole-2,5-dicarboxylate 2-[4-(2,2,3,3,4,4,4-heptafluorobutyloxy)-2-picolylsulfinyl]-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-(3,5-Dimethyl-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 4,6-Dimethyl-2-(pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-Ethoxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole 2-(4-Methoxy-pyridin-2-ylmethanesulfinyl)-4,6-dimethyl-1H-thieno[3,4-d]imidazole 2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid amide 4-phenyl-2-(pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole 2-bromo-4H-pyrrolo[3,2-d]thiazole-5-carboxylic acid 2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-4-(4-methoxyphenyl)-1H-thieno[3,4-d]imidazole

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