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    首页 分子通 2-(8-(3-cyano-4-isopropoxybenzyloxy)-10-cyclopropyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid

    2-(8-(3-cyano-4-isopropoxybenzyloxy)-10-cyclopropyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid | 1262007-66-8

    分子结构分类

    有机化合物 - 有机杂环化合物 - Pyrroloazepines
    中文名称
    ——
    中文别名
    ——
    英文名称
    2-(8-(3-cyano-4-isopropoxybenzyloxy)-10-cyclopropyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid
    英文别名
    2-[8-[(3-Cyano-4-propan-2-yloxyphenyl)methoxy]-10-cyclopropyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl]acetic acid
    2-(8-(3-cyano-4-isopropoxybenzyloxy)-10-cyclopropyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-1-yl)acetic acid化学式
    CAS
    1262007-66-8
    化学式
    C27H29N3O4
    mdl
    ——
    分子量
    459.545
    InChiKey
    KVOGENVYPBEUEW-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      1.2
    • 重原子数：
      34
    • 可旋转键数：
      8
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.41
    • 拓扑面积：
      96.5
    • 氢给体数：
      2
    • 氢受体数：
      6

    文献信息

    • [EN] MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO<br/>[FR] MODULATEURS DU RÉCEPTEUR SPHINGOSINE-1-PHOSPHATE (S1P) UTILES POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À CEUX-CI
      申请人：ARENA PHARM INC
      公开号：WO2011005295A1
      公开（公告）日：2011-01-13
      The present invention relates to certain compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.
    查看更多

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