1-(4-fluorophenyl)-N-[1-(6-methylsulfonylpyridin-3-yl)butyl]-6,7-dihydro-5H-pyrazolo[4,3-b]pyridine-4-carboxamide | 1383734-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-fluorophenyl)-N-[1-(6-methylsulfonylpyridin-3-yl)butyl]-6,7-dihydro-5H-pyrazolo[4,3-b]pyridine-4-carboxamide
• CAS: 1383734-05-1
• 化学式: C₂₃H₂₆FN₅O₃S
• 分子量: 471.556
• InChiKey: AGZLSEHFVXPQJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS DE PYRAZOLOPIPÉRIDINE EN TANT QU'ANTAGONISTES DE RÉCEPTEUR CCR1
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012087782A1

  公开（公告）日：2012-06-28

  Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

  揭示了一种公式（I）的化合物，可用于治疗多种通过CCR1活性介导或维持的疾病和紊乱，包括自身免疫性疾病，如类风湿性关节炎和多发性硬化症。还公开了制备方法和使用方法。
• PYRAZOLOPIPERIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2655371B1

  公开（公告）日：2015-02-25
• Pyrazolopiperidine Compounds As CCR1 Receptor Antagonists
  申请人：BETAGERI Rajashekhar

  公开号：US20120322790A1

  公开（公告）日：2012-12-20

  Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
• US8546442B2
  申请人：——

  公开号：US8546442B2

  公开（公告）日：2013-10-01